(R)-7-(2-benzyl-1H-imidazol-1-yl)-5-cyclopentyl-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine

Base Information

Chemical Name:(R)-7-(2-benzyl-1H-imidazol-1-yl)-5-cyclopentyl-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine
CAS No.:1371620-67-5
Molecular Formula:C₂₅H₂₈N₈
Molecular Weight:440.551
Hs Code.:

Synonyms:(R)-7-(2-benzyl-1H-imidazol-1-yl)-5-cyclopentyl-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine

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Chemical Property of (R)-7-(2-benzyl-1H-imidazol-1-yl)-5-cyclopentyl-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine

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Technology Process of (R)-7-(2-benzyl-1H-imidazol-1-yl)-5-cyclopentyl-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine

There total 4 articles about (R)-7-(2-benzyl-1H-imidazol-1-yl)-5-cyclopentyl-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1371620-51-7
(R)-7-(2-bromo-1H-imidazol-1-yl)-5-cyclopentyl-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine

: 62673-31-8
benzyl(bromo)zinc

: 1371620-67-5
(R)-7-(2-benzyl-1H-imidazol-1-yl)-5-cyclopentyl-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine

Guidance literature:: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; johnphos; In tetrahydrofuran; at 90 ℃; for 18h; Inert atmosphere; Sealed tube;

Reference yield:

: 755039-53-3
(R)-methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(cyclopentyl)-amino)butanoate

: 1371620-67-5
(R)-7-(2-benzyl-1H-imidazol-1-yl)-5-cyclopentyl-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / 1-methyl-pyrrolidin-2-one / 6 h / 90 °C

2.1: acetic acid; iron / 0.67 h / 42 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -20 - 0 °C

3.2: -40 - 20 °C

4.1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; johnphos / tetrahydrofuran / 18 h / 90 °C / Inert atmosphere; Sealed tube

With potassium tert-butylate; iron; sodium carbonate; acetic acid; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; johnphos; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;

Reference yield:

: 1313520-94-3
C₁₇H₂₁BrN₆O₄

: 1371620-67-5
(R)-7-(2-benzyl-1H-imidazol-1-yl)-5-cyclopentyl-4-ethyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; iron / 0.67 h / 42 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -20 - 0 °C

2.2: -40 - 20 °C

3.1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; johnphos / tetrahydrofuran / 18 h / 90 °C / Inert atmosphere; Sealed tube

With potassium tert-butylate; iron; acetic acid; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; johnphos; In tetrahydrofuran;