2,2,2-trichloroacetimidic acid (Z)-1-phenyl-4-(2,2,2-trichloroacetimidoyloxy)but-2-enyl ester

Base Information

Chemical Name:2,2,2-trichloroacetimidic acid (Z)-1-phenyl-4-(2,2,2-trichloroacetimidoyloxy)but-2-enyl ester
CAS No.:1307904-92-2
Molecular Formula:C₁₄H₁₂Cl₆N₂O₂
Molecular Weight:452.979
Hs Code.:

Synonyms:2,2,2-trichloroacetimidic acid (Z)-1-phenyl-4-(2,2,2-trichloroacetimidoyloxy)but-2-enyl ester

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Chemical Property of 2,2,2-trichloroacetimidic acid (Z)-1-phenyl-4-(2,2,2-trichloroacetimidoyloxy)but-2-enyl ester

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Technology Process of 2,2,2-trichloroacetimidic acid (Z)-1-phenyl-4-(2,2,2-trichloroacetimidoyloxy)but-2-enyl ester

There total 3 articles about 2,2,2-trichloroacetimidic acid (Z)-1-phenyl-4-(2,2,2-trichloroacetimidoyloxy)but-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 62499-97-2
(Z)-1,4-dihydroxy-1-phenylbut-2-ene

: 545-06-2
trichloroacetonitrile

: 1307904-92-2
2,2,2-trichloroacetimidic acid (Z)-1-phenyl-4-(2,2,2-trichloroacetimidoyloxy)but-2-enyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; for 2.5h; Inert atmosphere; Molecular sieve;
DOI:10.1002/ejoc.201100060

Reference yield:

: 29021-82-7
1-phenylbut-2-yne-1,4-diol

: 1307904-92-2
2,2,2-trichloroacetimidic acid (Z)-1-phenyl-4-(2,2,2-trichloroacetimidoyloxy)but-2-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Pd-BaSO₄; hydrogen / pyridine / 1.5 h / 760.05 Torr

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 2.5 h / 0 °C / Inert atmosphere; Molecular sieve

With Pd-BaSO₄; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; dichloromethane;
DOI:10.1002/ejoc.201100060

Reference yield:

: 100-52-7
benzaldehyde

: 1307904-92-2
2,2,2-trichloroacetimidic acid (Z)-1-phenyl-4-(2,2,2-trichloroacetimidoyloxy)but-2-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: Pd-BaSO₄; hydrogen / pyridine / 1.5 h / 760.05 Torr

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 2.5 h / 0 °C / Inert atmosphere; Molecular sieve

With n-butyllithium; Pd-BaSO₄; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; pyridine; hexane; dichloromethane;
DOI:10.1002/ejoc.201100060