(5R,7S)-8-(3-isopropoxybenzyl)-7-methyl-1-(6-methylpyridin-2-yl)-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

Base Information

Chemical Name:(5R,7S)-8-(3-isopropoxybenzyl)-7-methyl-1-(6-methylpyridin-2-yl)-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide
CAS No.:1338819-94-5
Molecular Formula:C₂₄H₃₁N₃O₃S
Molecular Weight:441.594
Hs Code.:

Synonyms:(5R,7S)-8-(3-isopropoxybenzyl)-7-methyl-1-(6-methylpyridin-2-yl)-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

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Chemical Property of (5R,7S)-8-(3-isopropoxybenzyl)-7-methyl-1-(6-methylpyridin-2-yl)-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

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Technology Process of (5R,7S)-8-(3-isopropoxybenzyl)-7-methyl-1-(6-methylpyridin-2-yl)-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

There total 11 articles about (5R,7S)-8-(3-isopropoxybenzyl)-7-methyl-1-(6-methylpyridin-2-yl)-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 184970-27-2
1-(bromomethyl)-3-isopropoxybenzene

: 1338821-49-0
(5R,7S)-7-methyl-1-(6-methylpyridin-2-yl)-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

: 1338819-94-5
(5R,7S)-8-(3-isopropoxybenzyl)-7-methyl-1-(6-methylpyridin-2-yl)-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

Guidance literature:: With potassium carbonate; In acetonitrile; for 20h;

Reference yield:

: 790667-49-1
(S)-2-methyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester

: 1338819-94-5
(5R,7S)-8-(3-isopropoxybenzyl)-7-methyl-1-(6-methylpyridin-2-yl)-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

1.2: 16 h / 20 °C

2.1: diisobutylaluminium hydride / toluene / 18 h / -78 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 2 h / 0 - 20 °C

4.1: potassium carbonate / 5,5-dimethyl-1,3-cyclohexadiene / 72 h / 140 °C

5.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C

6.1: pyridine / dichloromethane / 18.25 h / 0 - 20 °C

7.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 18 h / 80 °C

8.1: caesium carbonate; palladium diacetate; 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole / toluene / 20 h / 110 °C / Sealed tube

9.1: hydrogenchloride / methanol; 1,4-dioxane / 20 h

10.1: potassium carbonate / acetonitrile / 20 h

With pyridine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; hydrogenchloride; palladium diacetate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1338821-09-2
tert-butyl (2S)-4-(2-methoxy-2-oxoethylidene)-2-methylpiperidine-1-carboxylate

: 1338819-94-5
(5R,7S)-8-(3-isopropoxybenzyl)-7-methyl-1-(6-methylpyridin-2-yl)-2-thia-1,8-diazaspiro[4.5]dec-3-ene 2,2-dioxide

Guidance literature:: Multi-step reaction with 9 steps

1: diisobutylaluminium hydride / toluene / 18 h / -78 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 2 h / 0 - 20 °C

3: potassium carbonate / 5,5-dimethyl-1,3-cyclohexadiene / 72 h / 140 °C

4: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C

5: pyridine / dichloromethane / 18.25 h / 0 - 20 °C

6: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 18 h / 80 °C

7: caesium carbonate; palladium diacetate; 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole / toluene / 20 h / 110 °C / Sealed tube

8: hydrogenchloride / methanol; 1,4-dioxane / 20 h

9: potassium carbonate / acetonitrile / 20 h

With pyridine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; hydrogenchloride; palladium diacetate; diisobutylaluminium hydride; potassium carbonate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; toluene; acetonitrile;