2-(3,4-dihydro-3-methyl-2-oxo-2H-1,3-benzoxazin-4-yl)-1-phenyl-1,3-butanedione

Base Information

• Chemical Name: 2-(3,4-dihydro-3-methyl-2-oxo-2H-1,3-benzoxazin-4-yl)-1-phenyl-1,3-butanedione
• CAS No.: 7646-18-6
• Molecular Formula: C₁₉H₁₇NO₄
• Molecular Weight: 323.348

Synonyms:2-(3,4-dihydro-3-methyl-2-oxo-2H-1,3-benzoxazin-4-yl)-1-phenyl-1,3-butanedione

Chemical Property of 2-(3,4-dihydro-3-methyl-2-oxo-2H-1,3-benzoxazin-4-yl)-1-phenyl-1,3-butanedione

Chemical Property:

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Technology Process of 2-(3,4-dihydro-3-methyl-2-oxo-2H-1,3-benzoxazin-4-yl)-1-phenyl-1,3-butanedione

There total 4 articles about 2-(3,4-dihydro-3-methyl-2-oxo-2H-1,3-benzoxazin-4-yl)-1-phenyl-1,3-butanedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3'-dimethyl-3,4,3',4'-tetrahydro-4,4'-oxy-bis-benzo[e][1,3]oxazin-2-one (7690-99-5) → 2-(3,4-dihydro-3-methyl-2-oxo-2H-1,3-benzoxazin-4-yl)-1-phenyl-1,3-butanedione (7646-18-6)

Guidance literature:

Multi-step reaction with 2 steps

1: TsOH*H₂O / aq. ethanol / 0.5 h / Heating

2: TsOH*H₂O / benzene / Heating

With toluene-4-sulfonic acid; In ethanol; benzene;

DOI:10.1021/jo01279a024

Reference yield:

salicylaldehyde (90-02-8) → 2-(3,4-dihydro-3-methyl-2-oxo-2H-1,3-benzoxazin-4-yl)-1-phenyl-1,3-butanedione (7646-18-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / diethyl ether / Ambient temperature

2: TsOH*H₂O / benzene / Heating

With toluene-4-sulfonic acid; triethylamine; In diethyl ether; benzene;

DOI:10.1021/jo01279a024

Reference yield:

1-phenylbutan-1,3-dione (93-91-4) + 3,4-dihydro-4-hydroxy-3-methyl-2H-1,3-benzoxazin-2-one (941-88-8) → 2-(3,4-dihydro-3-methyl-2-oxo-2H-1,3-benzoxazin-4-yl)-1-phenyl-1,3-butanedione (7646-18-6)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; Heating;

DOI:10.1021/jo01279a024

upstream raw materials:

1-phenylbutan-1,3-dione

3,4-dihydro-4-hydroxy-3-methyl-2H-1,3-benzoxazin-2-one

3,3'-dimethyl-3,4,3',4'-tetrahydro-4,4'-oxy-bis-benzo[e][1,3]oxazin-2-one

salicylaldehyde

Downstream raw materials:

3,4-dihydro-3-methyl-4-(3-methyl-5-phenyl-1H-pyrazol-4-yl)-2H-1,3-benzoxazin-2-one

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