(R)-3-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-N-{(S)-1-[(S)-1-((S)-2-ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-succinamic acid

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Chemical Name:(R)-3-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-N-{(S)-1-[(S)-1-((S)-2-ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-succinamic acid
CAS No.:171976-93-5
Molecular Formula:C₃₅H₅₆N₁₀O₁₀
Molecular Weight:776.891
Hs Code.:

(R)-3-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-N-{(S)-1-[(S)-1-((S)-2-ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-succinamic acid

Synonyms:(R)-3-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-N-{(S)-1-[(S)-1-((S)-2-ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-succinamic acid

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Chemical Property of (R)-3-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-N-{(S)-1-[(S)-1-((S)-2-ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-succinamic acid

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Technology Process of (R)-3-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-N-{(S)-1-[(S)-1-((S)-2-ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-succinamic acid

There total 4 articles about (R)-3-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-N-{(S)-1-[(S)-1-((S)-2-ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 171976-97-9
Z-Ser-Tyr-D-Asp(OBzl)-Leu-Arg(NO₂)-Pro-NHEt

: 171976-93-5
(R)-3-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-N-{(S)-1-[(S)-1-((S)-2-ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-succinamic acid

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In methanol;
DOI:10.1007/BF00629874

Reference yield:

: 58111-84-5
Z-L-Ser-L-Tyr-N₃

: 171976-93-5
(R)-3-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-N-{(S)-1-[(S)-1-((S)-2-ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-succinamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / dioxane / 1.) -30 deg C, 1 h, 2.) -15 deg C, 1 h, 3.) 0 deg C, 1 day, 4.) RT, 1 day

2: 73 percent / Et₃N, diphenylphosphorazidate / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 2 days

3: 94 percent / H₂, aq. AcOH / Pd/C / methanol

With diphenyl phosphoryl azide; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1007/BF00629874

Reference yield:

: 55610-27-0
Z-L-Ser-L-Tyr-N₂H₃

: 171976-93-5
(R)-3-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-N-{(S)-1-[(S)-1-((S)-2-ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-succinamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tert-butyl nitrite, HCl / dioxane / 0.75 h / 0 °C

2: Et₃N / dioxane / 1.) -30 deg C, 1 h, 2.) -15 deg C, 1 h, 3.) 0 deg C, 1 day, 4.) RT, 1 day

3: 73 percent / Et₃N, diphenylphosphorazidate / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 2 days

4: 94 percent / H₂, aq. AcOH / Pd/C / methanol

With hydrogenchloride; tert.-butylnitrite; diphenyl phosphoryl azide; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1007/BF00629874