(3S)-3-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid

Base Information

Chemical Name:(3S)-3-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid
CAS No.:341508-53-0
Molecular Formula:C₂₂H₃₃N₃O₆
Molecular Weight:435.521
Hs Code.:

Synonyms:(3S)-3-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid

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Chemical Property of (3S)-3-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid

Chemical Property:

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Technology Process of (3S)-3-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid

There total 6 articles about (3S)-3-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 341508-52-9
(3S)-3-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid methyl ester

: 341508-53-0
(3S)-3-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃;
DOI:10.1021/jo001308b

Reference yield:

: 31972-52-8
Boc-Gly-Gly-OH

: 341508-53-0
(3S)-3-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; HOBt; Et₃N / dimethylformamide / 20 °C

2: LiOH / H₂O; tetrahydrofuran / 0 - 20 °C

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jo001308b

Reference yield:

: 341508-48-3
(S)-hexahydro-6-benzyl-2H-azepin-2-one

: 341508-53-0
(3S)-3-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: HCl / H₂O / Heating

2: SOCl₂ / 0 - 20 °C

3: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; HOBt; Et₃N / dimethylformamide / 20 °C

4: LiOH / H₂O; tetrahydrofuran / 0 - 20 °C

With hydrogenchloride; lithium hydroxide; thionyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jo001308b