Technology Process of ethyl <6-(benzyloxy)-2-chloro-3,4-dihydroquinazolin-3-yl>acetate
There total 8 articles about ethyl <6-(benzyloxy)-2-chloro-3,4-dihydroquinazolin-3-yl>acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 90 percent / tetra-n-butylammonium hydrogen sulfate, KMnO4 / acetone / 40 °C
2: oxalyl chloride / benzene; dimethylformamide / Ambient temperature
3: 86 percent / 0.5 h / Heating
4: 78 percent / aq. NiCl2 NaBH4 / methanol / Ambient temperature
5: 81 percent / acetic acid; H2O
6: 1.) aq. NaOH, 2.) POCl3, N,N-dimethylaniline / 1.) methanol, heating, 2.) 140 deg C, 2 h
7: 92 percent / NaBH4 / CHCl3; ethanol / 0 °C
8: 68 percent / K2CO3 / butan-2-one
With
sodium hydroxide; sodium tetrahydroborate; potassium permanganate; oxalyl dichloride; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; N,N-dimethyl-aniline; nickel dichloride; trichlorophosphate;
In
methanol; ethanol; chloroform; water; acetic acid; N,N-dimethyl-formamide; acetone; butanone; benzene;
DOI:10.1021/jm00119a014
- Guidance literature:
-
Multi-step reaction with 7 steps
1: oxalyl chloride / benzene; dimethylformamide / Ambient temperature
2: 86 percent / 0.5 h / Heating
3: 78 percent / aq. NiCl2 NaBH4 / methanol / Ambient temperature
4: 81 percent / acetic acid; H2O
5: 1.) aq. NaOH, 2.) POCl3, N,N-dimethylaniline / 1.) methanol, heating, 2.) 140 deg C, 2 h
6: 92 percent / NaBH4 / CHCl3; ethanol / 0 °C
7: 68 percent / K2CO3 / butan-2-one
With
sodium hydroxide; sodium tetrahydroborate; oxalyl dichloride; potassium carbonate; N,N-dimethyl-aniline; nickel dichloride; trichlorophosphate;
In
methanol; ethanol; chloroform; water; acetic acid; N,N-dimethyl-formamide; butanone; benzene;
DOI:10.1021/jm00119a014
