C₄₂H₅₉N₅O₉

Base Information

• Chemical Name: C₄₂H₅₉N₅O₉
• CAS No.: 1219818-09-3
• Molecular Formula: C₄₂H₅₉N₅O₉
• Molecular Weight: 777.959
• Mol file: 1219818-09-3.mol

Synonyms:C₄₂H₅₉N₅O₉

Chemical Property of C₄₂H₅₉N₅O₉

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₂H₅₉N₅O₉

There total 7 articles about C₄₂H₅₉N₅O₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H33N3O5 (1219818-11-7) + (2S,3'S)-2-isobutyl-2-[4'-(tert-butoxycarbonyl)-3'-methyl-2'-oxopiperazin-1'-yl]acetic acid (186821-12-5) → C42H59N5O9 (1219818-09-3)

Guidance literature:

(2S,3'S)-2-isobutyl-2-[4'-(tert-butoxycarbonyl)-3'-methyl-2'-oxopiperazin-1'-yl]acetic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 25 ℃; for 0.25h;

C₂₆H₃₃N₃O₅; In N,N-dimethyl-formamide; at 55 ℃; for 48h;

DOI:10.1021/ol1003143

Reference yield:

N-allylated leucine methyl ester (73270-65-2) → C42H59N5O9 (1219818-09-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 25 °C

1.2: Reflux

2.1: ozone / methanol / 4.17 h / -78 °C

2.2: 16 h / 20 °C

2.3: 24 h / 25 °C

3.1: 4-methyl-morpholine / dichloromethane / 6 h / 0 - 25 °C / Reflux

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 2 h / 0 °C

4.2: pH 3

5.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 20 °C

5.2: 48 h / 55 °C

With 4-methyl-morpholine; lithium hydroxide monohydrate; water; benzotriazol-1-ol; ozone; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

Boc-Ala-N(allyl)-Leu-OMe (1219818-08-2) → C42H59N5O9 (1219818-09-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ozone / methanol / 4.17 h / -78 °C

1.2: 16 h / 20 °C

1.3: 24 h / 25 °C

2.1: 4-methyl-morpholine / dichloromethane / 6 h / 0 - 25 °C / Reflux

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 2 h / 0 °C

3.2: pH 3

4.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 48 h / 55 °C

With 4-methyl-morpholine; lithium hydroxide monohydrate; water; benzotriazol-1-ol; ozone; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

C₂₆H₃₃N₃O₅

(2S,3'S)-2-isobutyl-2-[4'-(tert-butoxycarbonyl)-3'-methyl-2'-oxopiperazin-1'-yl]acetic acid

methyl (2S)-2-amino-3-phenylpropanoate

N-allylated leucine methyl ester