1'-[4-(1-pyrrolidinylcarbonyl)phenyl]-3'-(trifluoromethyl)-1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole]

Base Information

Chemical Name:1'-[4-(1-pyrrolidinylcarbonyl)phenyl]-3'-(trifluoromethyl)-1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole]
CAS No.:1092459-48-7
Molecular Formula:C₂₁H₂₂F₃N₃O₃
Molecular Weight:421.419
Hs Code.:

Synonyms:1'-[4-(1-pyrrolidinylcarbonyl)phenyl]-3'-(trifluoromethyl)-1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole]

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Chemical Property of 1'-[4-(1-pyrrolidinylcarbonyl)phenyl]-3'-(trifluoromethyl)-1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole]

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Technology Process of 1'-[4-(1-pyrrolidinylcarbonyl)phenyl]-3'-(trifluoromethyl)-1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole]

There total 4 articles about 1'-[4-(1-pyrrolidinylcarbonyl)phenyl]-3'-(trifluoromethyl)-1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 168317-99-5
(4-iodophenyl)(pyrrolidin-1-yl)methanone

: 1092459-45-4
3'-(trifluoromethyl)-1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole]

: 1092459-48-7
1'-[4-(1-pyrrolidinylcarbonyl)phenyl]-3'-(trifluoromethyl)-1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole]

Guidance literature:: With potassium carbonate; copper(l) iodide; dimethylaminoacetic acid; In dimethyl sulfoxide; at 130 - 150 ℃; for 6h;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1092459-48-7
1'-[4-(1-pyrrolidinylcarbonyl)phenyl]-3'-(trifluoromethyl)-1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole]

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / Cooling with methanol-dry ice

1.2: 16 h / 20 °C / Cooling with methanol-dry ice

2.1: hydrazine / ethanol / 1 h / 80 °C

3.1: potassium carbonate / copper(l) iodide; dimethylaminoacetic acid / dimethyl sulfoxide / 6 h / 130 - 150 °C

With potassium carbonate; hydrazine; lithium diisopropyl amide; copper(l) iodide; dimethylaminoacetic acid; In tetrahydrofuran; ethanol; dimethyl sulfoxide;

Reference yield:

: 619-58-9
4-iodobenzoic acid

: 1092459-48-7
1'-[4-(1-pyrrolidinylcarbonyl)phenyl]-3'-(trifluoromethyl)-1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole]

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.58 h

1.2: 1.25 h / 20 °C

2.1: potassium carbonate / copper(l) iodide; dimethylaminoacetic acid / dimethyl sulfoxide / 6 h / 130 - 150 °C

With potassium carbonate; 1,1'-carbonyldiimidazole; copper(l) iodide; dimethylaminoacetic acid; In dichloromethane; dimethyl sulfoxide;