ethyl 5-(4-chlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

Base Information

Chemical Name:ethyl 5-(4-chlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate
CAS No.:512826-18-5
Molecular Formula:C₁₆H₁₁ClF₃N₃O₂
Molecular Weight:369.73
Hs Code.:

Synonyms:ethyl 5-(4-chlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

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Chemical Property of ethyl 5-(4-chlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

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Technology Process of ethyl 5-(4-chlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

There total 2 articles about ethyl 5-(4-chlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1260243-04-6,6994-25-8
ethyl 5-amino-1H-pyrazole-4-carboxylate

: 18931-60-7
1-(4-chlorophenyl)-4,4,4-trifluorobutane-1,3-dione

: 512826-18-5
ethyl 5-(4-chlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

Guidance literature:: With acetic acid; for 4h; Reflux;
DOI:10.1016/j.bmc.2010.10.035

Reference yield:

: 6994-25-8,103259-35-4,19750-02-8
3-amino-4-pyrazolecarboxylic acid ethyl ester

: 18931-60-7
1-(4-chlorophenyl)-4,4,4-trifluorobutane-1,3-dione

: 512826-18-5
ethyl 5-(4-chlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

Guidance literature:: In acetic acid; for 0.283333h; Microwave irradiation;
DOI:10.5012/jkcs.2011.55.4.719

Reference yield: 81.0%

: 512826-18-5
ethyl 5-(4-chlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

: 667920-68-5
ethyl 5-(4-chlorophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate

Guidance literature:: ethyl 5-(4-chlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate; With sodium tetrahydroborate; In methanol; at 20 ℃; for 5h;

With citric acid; In methanol; diastereoselective reaction; Saturated solution;
DOI:10.1016/j.bmc.2010.10.035