(2R,3R,5S)-3,5-diethyl-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methylpiperidine

Base Information

Chemical Name:(2R,3R,5S)-3,5-diethyl-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methylpiperidine
CAS No.:890149-98-1
Molecular Formula:C₁₈H₂₉NO
Molecular Weight:275.434
Hs Code.:

Synonyms:(2R,3R,5S)-3,5-diethyl-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methylpiperidine

Suppliers and Price of (2R,3R,5S)-3,5-diethyl-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methylpiperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R,5S)-3,5-diethyl-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methylpiperidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R,5S)-3,5-diethyl-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methylpiperidine

There total 2 articles about (2R,3R,5S)-3,5-diethyl-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 890150-30-8
(3R,6S,8R,8aS)-6,8-diethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: 890149-98-1
(2R,3R,5S)-3,5-diethyl-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methylpiperidine

Guidance literature:: With borane; In tetrahydrofuran; at -78 - 0 ℃; for 6.25h;
DOI:10.1021/jo060157v

Reference yield:

: 430461-26-0
(3R,8R,8aS)-8-ethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: 890149-98-1
(2R,3R,5S)-3,5-diethyl-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: tetrahydrofuran / 2 h

2.1: 64 percent / BH₃ / tetrahydrofuran / 6.25 h / -78 - 0 °C

With borane; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/jo060157v