(3R,8R,8aS)-8-ethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Base Information

Chemical Name:(3R,8R,8aS)-8-ethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
CAS No.:430461-26-0
Molecular Formula:C₁₆H₂₁NO₂
Molecular Weight:259.348
Hs Code.:

Synonyms:(3R,8R,8aS)-8-ethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

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Chemical Property of (3R,8R,8aS)-8-ethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

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Technology Process of (3R,8R,8aS)-8-ethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

There total 1 articles about (3R,8R,8aS)-8-ethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 39517-97-0
4-ethyl-5-oxohexanoic acid

: 56613-80-0
D-2-phenylglycinol

: (3R,8S,8aR)-8-ethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: 430461-26-0
(3R,8R,8aS)-8-ethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: In toluene; for 24h; Heating;
DOI:10.1002/chem.200600420

Reference yield: 84.0%

: 430461-26-0
(3R,8R,8aS)-8-ethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: 439085-06-0
(2R,3R)-3-ethyl-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methylpiperidine

Guidance literature:: With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; at -78 - 20 ℃; for 2.5h;
DOI:10.1002/chem.200600420

Reference yield: 25.0%

: 100-39-0
benzyl bromide

: 430461-26-0
(3R,8R,8aS)-8-ethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: (3R,6S,8R,8aS)-6-benzyl-8-ethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: (3R,6R,8R,8aS)-6-benzyl-8-ethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: (3R,8R,8aS)-6,6-dibenzyl-8-ethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: (3R,8R,8aS)-8-ethyl-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

benzyl bromide; In tetrahydrofuran; for 2h;
DOI:10.1021/jo060157v