3-chloro-N-[1-(4-chlorophenyl)-1-methylethyl]propionamide

Base Information

• Chemical Name: 3-chloro-N-[1-(4-chlorophenyl)-1-methylethyl]propionamide
• CAS No.: 151946-42-8
• Molecular Formula: C₁₂H₁₅Cl₂NO
• Molecular Weight: 260.163
• DSSTox Substance ID: DTXSID301236429
• Mol file: 151946-42-8.mol

Synonyms:SCHEMBL8949430;3-chloro-N-[1-(4-chlorophenyl)-1-methylethyl]propionamide;URPUFDUMAHCAEU-UHFFFAOYSA-N;DTXSID301236429;151946-42-8;3-Chloro-N-[1-(4-chlorophenyl)-1-methylethyl]propanamide

Chemical Property of 3-chloro-N-[1-(4-chlorophenyl)-1-methylethyl]propionamide

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 259.0530695
• Heavy Atom Count: 16
• Complexity: 235

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C1=CC=C(C=C1)Cl)NC(=O)CCCl

Technology Process of 3-chloro-N-[1-(4-chlorophenyl)-1-methylethyl]propionamide

There total 1 articles about 3-chloro-N-[1-(4-chlorophenyl)-1-methylethyl]propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-(4-chlorophenyl)propan-2-amine hydrochloride (151946-41-7) + 2-chloropropionyl chloride (625-36-5) → 3-chloro-N-[1-(4-chlorophenyl)-1-methylethyl]propionamide (151946-42-8) + N-[1-(4-chlorophenyl)-1-methylethyl]-acrylamide (31220-69-6)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield:

1H-imidazole (288-32-4) + 3-chloro-N-[1-(4-chlorophenyl)-1-methylethyl]propionamide (151946-42-8) → N-[1-(4-chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propionamide

Guidance literature:

In tetrahydrofuran;

Reference yield:

2-methylimidazole (693-98-1) + 3-chloro-N-[1-(4-chlorophenyl)-1-methylethyl]propionamide (151946-42-8) → N-[1-(4-chlorophenyl)-1-methylethyl]-3-(2-methylimidazol-1-yl)propionamide

Guidance literature:

In tetrahydrofuran;

upstream raw materials:

2-(4-chlorophenyl)propan-2-amine hydrochloride

2-chloropropionyl chloride