2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-vinyl-pyrazin-2-yl)propionamide

Base Information

• Chemical Name: 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-vinyl-pyrazin-2-yl)propionamide
• CAS No.: 710322-80-8
• Molecular Formula: C₂₁H₂₄ClN₃O₃S
• Molecular Weight: 433.959
• Mol file: 710322-80-8.mol

Synonyms:2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-vinyl-pyrazin-2-yl)propionamide

Chemical Property of 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-vinyl-pyrazin-2-yl)propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-vinyl-pyrazin-2-yl)propionamide

There total 1 articles about 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-vinyl-pyrazin-2-yl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid (300356-14-3) + 2-amino-5-ethenylpyrazine (620596-94-3) → 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-vinyl-pyrazin-2-yl)propionamide (710322-80-8)

Guidance literature:

(R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 0.5h;

2-amino-5-ethenylpyrazine; With 2,6-dimethylpyridine; In tetrahydrofuran; at 25 ℃; for 16h;

Reference yield: 34.0%

2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-vinyl-pyrazin-2-yl)propionamide (710322-80-8) → 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-[5-1(R),2-dihydroxy-ethyl-pyrazin-2-yl]-propionamide (710321-77-0)

Guidance literature:

2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-vinyl-pyrazin-2-yl)propionamide; With osmium(VIII) oxide; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III); In water; toluene; tert-butyl alcohol; at 0 ℃; Inert atmosphere;

With sodium metabisulfite; ethyl acetate; In water; toluene; tert-butyl alcohol; for 0.25h; Inert atmosphere;

DOI:10.1021/ml400027y

Reference yield:

2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-vinyl-pyrazin-2-yl)propionamide (710322-80-8) → (R)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-[5-((S)-1,2-dihydroxy-ethyl)-pyrazin-2-yl]-propionamide (710321-76-9)

Guidance literature:

With hydroquinine 1,4-phthalazinediyl diether; potassium carbonate; potassium hexacyanoferrate(III); In water; tert-butyl alcohol; at 25 ℃; for 0.0833333h;

2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-vinyl-pyrazin-2-yl)propionamide; With osmium(VIII) oxide; In water; toluene; tert-butyl alcohol; for 18h;

upstream raw materials:

(R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid

2-amino-5-ethenylpyrazine

Downstream raw materials:

(R)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-[5-((S)-1,2-dihydroxy-ethyl)-pyrazin-2-yl]-propionamide

2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-[5-1(R),2-dihydroxy-ethyl-pyrazin-2-yl]-propionamide

2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-[5-(1 (S), 2-dihydroxy-ethyl)-pyrazin-2-yl]-propionamide