(1'S,4'S,5'S)-(-)-3-<4'-(2-Ethinyl-1,3-dioxolan-2-ylmethyl)-5'-(4-methoxybenzyloxy)-3'-methylcyclopent-2'-enyl>-2,2-dimethyl-propionaldehyd

Base Information

Chemical Name:(1'S,4'S,5'S)-(-)-3-<4'-(2-Ethinyl-1,3-dioxolan-2-ylmethyl)-5'-(4-methoxybenzyloxy)-3'-methylcyclopent-2'-enyl>-2,2-dimethyl-propionaldehyd
CAS No.:154952-73-5
Molecular Formula:C₂₅H₃₂O₅
Molecular Weight:412.526
Hs Code.:

Synonyms:(1'S,4'S,5'S)-(-)-3-<4'-(2-Ethinyl-1,3-dioxolan-2-ylmethyl)-5'-(4-methoxybenzyloxy)-3'-methylcyclopent-2'-enyl>-2,2-dimethyl-propionaldehyd

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Chemical Property of (1'S,4'S,5'S)-(-)-3-<4'-(2-Ethinyl-1,3-dioxolan-2-ylmethyl)-5'-(4-methoxybenzyloxy)-3'-methylcyclopent-2'-enyl>-2,2-dimethyl-propionaldehyd

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Technology Process of (1'S,4'S,5'S)-(-)-3-<4'-(2-Ethinyl-1,3-dioxolan-2-ylmethyl)-5'-(4-methoxybenzyloxy)-3'-methylcyclopent-2'-enyl>-2,2-dimethyl-propionaldehyd

There total 6 articles about (1'S,4'S,5'S)-(-)-3-<4'-(2-Ethinyl-1,3-dioxolan-2-ylmethyl)-5'-(4-methoxybenzyloxy)-3'-methylcyclopent-2'-enyl>-2,2-dimethyl-propionaldehyd which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 154952-72-4
(1'S,4'S,5'S)-(+)-3-<4'-(2-Ethinyl-1,3-dioxolan-2-ylmethyl)-5'-(4-methoxybenzyloxy)-3'-methylcyclopent-2'-enyl>-2,2-dimethylpropan-1-ol

: 154952-73-5
(1'S,4'S,5'S)-(-)-3-<4'-(2-Ethinyl-1,3-dioxolan-2-ylmethyl)-5'-(4-methoxybenzyloxy)-3'-methylcyclopent-2'-enyl>-2,2-dimethyl-propionaldehyd

Guidance literature:: With aluminum oxide; 3 A molecular sieve; sodium acetate; pyridinium chlorochromate; In dichloromethane; for 2h; Ambient temperature;

Reference yield:

: 154952-68-8
(1'S,4'S,5'S)-2-<4'-<3-(tert-Butyldimethylsilyloxy)-2,2-dimethylpropyl>-5'-(4-methoxybenzyloxy)-2'-methylcyclopent-2'-enyl>acetaldehyd

: 154952-73-5
(1'S,4'S,5'S)-(-)-3-<4'-(2-Ethinyl-1,3-dioxolan-2-ylmethyl)-5'-(4-methoxybenzyloxy)-3'-methylcyclopent-2'-enyl>-2,2-dimethyl-propionaldehyd

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 1.6M BuLi / 1.) THF, hexane, 0 deg C, 10 min; 2.) 0 deg C, 30 min

2: AcONa, molecular sieve (3 Angstroem), Al₂O₃, pyridinium chlorochromate / CH₂Cl₂ / 6 h

3: trimethylorthoformate, p-toluenesulfonic acid monohydrate / benzene / 1.) 6 h, RT; 2.) 6 h, reflux

4: Bu₄NF*3H₂O / tetrahydrofuran / 12 h / Ambient temperature

5: 79 percent / AcONa, molecular sieve (3 Angstroem), Al₂O₃, pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

With aluminum oxide; n-butyllithium; 3 A molecular sieve; tetrabutyl ammonium fluoride; sodium acetate; toluene-4-sulfonic acid; pyridinium chlorochromate; trimethyl orthoformate; In tetrahydrofuran; dichloromethane; benzene;

Reference yield:

: 154952-67-7
(1'S,4'S,5'S)-(+)-2-<4'-<3-(tert-Butyldimethylsilyloxy)-2,2-dimethylpropyl>-5'-(4-methoxybenzyloxy)-2'-methylcyclopent-2'-enyl>ethanol

: 154952-73-5
(1'S,4'S,5'S)-(-)-3-<4'-(2-Ethinyl-1,3-dioxolan-2-ylmethyl)-5'-(4-methoxybenzyloxy)-3'-methylcyclopent-2'-enyl>-2,2-dimethyl-propionaldehyd

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / AcONa, molecular sieve (3 Angstroem), Al₂O₃, pyridinium chlorochromate / CH₂Cl₂ / 3 h

2: 1.) 1.6M BuLi / 1.) THF, hexane, 0 deg C, 10 min; 2.) 0 deg C, 30 min

3: AcONa, molecular sieve (3 Angstroem), Al₂O₃, pyridinium chlorochromate / CH₂Cl₂ / 6 h

4: trimethylorthoformate, p-toluenesulfonic acid monohydrate / benzene / 1.) 6 h, RT; 2.) 6 h, reflux

5: Bu₄NF*3H₂O / tetrahydrofuran / 12 h / Ambient temperature

6: 79 percent / AcONa, molecular sieve (3 Angstroem), Al₂O₃, pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

With aluminum oxide; n-butyllithium; 3 A molecular sieve; tetrabutyl ammonium fluoride; sodium acetate; toluene-4-sulfonic acid; pyridinium chlorochromate; trimethyl orthoformate; In tetrahydrofuran; dichloromethane; benzene;