3,4-DIHYDRO-7-METHOXY-2H-1-NAPHTHALENONE-O-TOSYLOXIME

Base Information

• Chemical Name: 3,4-DIHYDRO-7-METHOXY-2H-1-NAPHTHALENONE-O-TOSYLOXIME
• CAS No.: 99833-87-1
• Molecular Formula: C18H19 N O4 S
• Molecular Weight: 345.41
• Hs Code.: 2928000090
• Mol file: 99833-87-1.mol

Synonyms:3,4-DIHYDRO-7-METHOXY-2H-1-NAPHTHALENONE-O-TOSYLOXIME;3,4-Dihydro-7-methoxy-1(2H)-naphthalenone O-[(4-Methylphenyl)sulfonyl]oxime

Chemical Property of 3,4-DIHYDRO-7-METHOXY-2H-1-NAPHTHALENONE-O-TOSYLOXIME

Chemical Property:

• Vapor Pressure: 5.57E-10mmHg at 25°C
• Melting Point: 133-134掳C
• Refractive Index: 1.597
• Boiling Point: 509.1°C at 760 mmHg
• Flash Point: 261.7°C
• PSA: 73.34000
• Density: 1.26g/cm³
• LogP: 4.53030
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

97% ^*data from raw suppliers

3,4-Dihydro-7-methoxy-2H-1-naphthalenone-O-tosyloxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,4-Dihydro-7-methoxy-2H-1-naphthalenone-O-tosyloxime (cas# 99833-87-1) is a compound useful in organic synthesis.

Technology Process of 3,4-DIHYDRO-7-METHOXY-2H-1-NAPHTHALENONE-O-TOSYLOXIME

There total 2 articles about 3,4-DIHYDRO-7-METHOXY-2H-1-NAPHTHALENONE-O-TOSYLOXIME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

7-methoxy-3,4-dihydronaphthalen-1(2H)-one oxime (20175-97-7) + p-toluenesulfonyl chloride (98-59-9) → 7-methoxy-1-tetralone O-tosyloxime (99833-87-1)

Guidance literature:

With potassium hydroxide; In acetone; for 3h; Ambient temperature;

Reference yield:

7-Methoxy-1-tetralone (6836-19-7) → 7-methoxy-1-tetralone O-tosyloxime (99833-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / NH₂OH*HCl, NaOH / ethanol / 2 h / Heating

2: 97 percent / aq. KOH / acetone / 3 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; hydroxylamine hydrochloride; In ethanol; acetone;

Reference yield:

7-methoxy-1-tetralone O-tosyloxime (99833-87-1) → Chloro-acetic acid (4S,5S)-4-[(2-chloro-acetyl)-propyl-amino]-8-methoxy-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

Guidance literature:

Multi-step reaction with 9 steps

1: 78 percent / acetic acid; H₂O / 60 °C

2: 86 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

3: 96 percent / pyridine / 3 h / Ambient temperature

4: 74 percent / CrO₃, aq. AcOH / Ambient temperature

5: 91 percent / isoamyl nitrite, HCl / diethyl ether / 1 h / Ambient temperature

6: 67 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 2327.2 Torr / Ambient temperature

7: NaBH₄ / ethanol / 1 h / Ambient temperature

8: 1.) BH₃*THF, 2.) aq. HCl / 1.) r.t., 3 h, 2.) reflux, 1 h

9: 62 percent / aq. NaOH / 1,2-dichloro-ethane / 1.) r.t., 30 min, 2.) r.t., overnight

With pyridine; chromium(VI) oxide; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; borane-THF; hydrogen; acetic acid; isopentyl nitrite; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; water; acetic acid; 1,2-dichloro-ethane;

upstream raw materials:

7-methoxy-3,4-dihydronaphthalen-1(2H)-one oxime

p-toluenesulfonyl chloride

7-Methoxy-1-tetralone

Downstream raw materials:

2-amino-7-methoxy-1-tetralone hydrochloride

8-methoxy-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one

8-methoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine

8-methoxy-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one