20175-97-7

Basic information

• Product Name: 7-Methoxy-1-tetralone Oxime
• Synonyms: 3,4-Dihydro-7-methoxy-1(2H)-naphthalenone Oxime;3,4-Dihydro-7-methoxy-2H-1-naphthalenoxime;7-Methoxy-1-tetralone Oxime
• CAS NO: 20175-97-7
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 20175-97-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 363.4°C at 760 mmHg
• Flash Point: 173.6°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 6.43E-06mmHg at 25°C
• Refractive Index: 1.578
• Solubility: Acetone, Chloroform, Dichloromethane, DMSO
• CAS DataBase Reference: 7-Methoxy-1-tetralone Oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Methoxy-1-tetralone Oxime(20175-97-7)
• EPA Substance Registry System: 7-Methoxy-1-tetralone Oxime(20175-97-7)

Safety Data

• Hazardous Substances Data: 20175-97-7(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

Uses

7-Methoxy-1-tetralone Oxime (cas# 20175-97-7) is a compound useful in organic synthesis.

InChI:InChI=1/C11H13NO2/c1-14-9-6-5-8-3-2-4-11(12-13)10(8)7-9/h5-7,13H,2-4H2,1H3/b12-11+

Upstream product

• 6836-19-7 7-Methoxy-1-tetralone 
• 24743-11-1 4-(m-methoxyphenyl)butanoic acid 
• 100-66-3 methoxybenzene 
• 38102-67-9 4-(3-methoxy-phenyl)-4-oxo-butyric acid 

Downstream Products

• 50399-51-4 trans-1,2,3,4-tetrahydro-7-methoxy-1-naphthylamine 
• 887354-63-4 C₁₈H₁₉NO₃S 
• 1439931-08-4 C₃₂H₃₀Cl₄N₂O₃ 
• 553611-27-1 C₁₈H₁₆ClF₃N₂O₂ 
• 22246-71-5 8-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepin-1-one 
• 200010-61-3 [5-Hydroxy-8-methoxy-4-[(E)-methoxyimino]-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-propynoic acid ethyl ester 

Relevant articles and documents

Design, synthesis and biological evaluation of brain penetrant benzazepine-based histone deacetylase 6 inhibitors for alleviating stroke-induced brain infarction

Histone deacetylase 6 (HDAC6) has become a promising therapeutic target for central nervous system diseases due to its more complex protein structure and biological functions. However, low brain penetration of reported HDAC6 inhibitors limits its clinical application in neurological disorders. Therefore, the benzazepine, a brain-penetrant rigid fragment, was utilized to design a series of selective HDAC6 inhibitors to improve brain bioavailability. Various synthetic strategies were applied to assemble the tetrahydro-benzazepine ring, and 22 compounds were synthesized. Among them, compound 5 showed low nanomolar potency and strong isozyme selectivity for the inhibition of HDAC6 (IC50 = 1.8 nM, 141-fold selectivity over HDAC1) with efficient binding patterns like coordination with the zinc ion and π-π stacking effect. Western blot results showed it could efficiently transport into SH-SY5Y cells and selectively enhance the acetylation level of α-tubulin with a moderate effect on Histone H3. Notably, pharmacokinetic studies demonstrated that compound 5 (brain/plasma ratio of 2.30) had an excellent ability to penetrate the blood-brain barrier of C57 mice. In male rats with transient middle cerebral artery occlusion (MCAO), compound 5 significantly reduced the cerebral infarction from 21.22% to 11.47% and alleviated neurobehavioral deficits in post-ischemic treatment, which provided a strong rationale for pursuing HDAC6-based therapies for ischemic stroke.

Catalyst free synthesis of mono- and disubstituted pyrimidines from O-acyl oximes

Transition-metal or iodine catalyzed transformations of O-acyl oximes to various N-heterocycles are well established. Herein, we report a catalyst free, oxime carboxylate based, three-component condensation method to access mono- and disubstituted pyrimidines. A broad range of substituted pyrimidines were prepared in moderate to excellent yields. Control experiments reveal that in situ generated formamidine is the key intermediate.

CARBOXY X RHODAMINE ANALOGS

The present invention provides novel fluorescent dyes and kits containing the same, which are useful for labeling a wide variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes f