(2R,3S,4R)-N-benzyl-3-hydroxy-2-(4-methoxybenzyl)-4-<(tert-butyldimethylsilyl)oxy>pyrrolidine

Base Information

Chemical Name:(2R,3S,4R)-N-benzyl-3-hydroxy-2-(4-methoxybenzyl)-4-<(tert-butyldimethylsilyl)oxy>pyrrolidine
CAS No.:163592-87-8
Molecular Formula:C₂₅H₃₇NO₃Si
Molecular Weight:427.659
Hs Code.:

Synonyms:(2R,3S,4R)-N-benzyl-3-hydroxy-2-(4-methoxybenzyl)-4-<(tert-butyldimethylsilyl)oxy>pyrrolidine

Suppliers and Price of (2R,3S,4R)-N-benzyl-3-hydroxy-2-(4-methoxybenzyl)-4-<(tert-butyldimethylsilyl)oxy>pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S,4R)-N-benzyl-3-hydroxy-2-(4-methoxybenzyl)-4-<(tert-butyldimethylsilyl)oxy>pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S,4R)-N-benzyl-3-hydroxy-2-(4-methoxybenzyl)-4-<(tert-butyldimethylsilyl)oxy>pyrrolidine

There total 12 articles about (2R,3S,4R)-N-benzyl-3-hydroxy-2-(4-methoxybenzyl)-4-<(tert-butyldimethylsilyl)oxy>pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 163661-11-8
(2R,3S,4R)-N-benzyl-3,4-dihydroxy-2-(4-methoxybenzyl)pyrrolidine

: 163592-87-8
(2R,3S,4R)-N-benzyl-3-hydroxy-2-(4-methoxybenzyl)-4-<(tert-butyldimethylsilyl)oxy>pyrrolidine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 0.833333h; Ambient temperature;

Reference yield:

: 922-65-6
divinylcarbinol

: 163592-87-8
(2R,3S,4R)-N-benzyl-3-hydroxy-2-(4-methoxybenzyl)-4-<(tert-butyldimethylsilyl)oxy>pyrrolidine

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) 4A molecular sieves, L-(+)-DIPT, TBHP, Ti(O-i-Pr)4, 2.) P(OEt)3, 3.) Ti(O-i-Pr)4

2: aq. NaHCO₃ / acetone / 3 h / Ambient temperature

3: 91.1 percent / PTS, NaHCO₃ / CH₂Cl₂

4: 74.9 percent / water, K₃Fe(CN)6, K₂CO₃, OsO₄ / 2-methyl-propan-2-ol / Ambient temperature

5: Et₃N / CH₂Cl₂ / 0 °C

6: K₂CO₃ / methanol / 0.33 h

7: 85.2 percent / CuI / tetrahydrofuran / -10 °C

8: DIBAL / toluene / 3 h / -78 °C

9: PPh₃, DEAD / CH₂Cl₂ / Ambient temperature

10: 80 percent / 2N aq. HCl / tetrahydrofuran

11: 89 percent / imidazole / dimethylformamide / 0.83 h / Ambient temperature

With 1H-imidazole; titanium(IV) isopropylate; hydrogenchloride; tert.-butylhydroperoxide; copper(l) iodide; osmium(VIII) oxide; L-(+)-diisopropyl tartrate; 4 A molecular sieve; water; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; triphenylphosphine; potassium hexacyanoferrate(III); diethylazodicarboxylate; triethyl phosphite; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;

Reference yield:

: 123533-17-5
(2R,3S)-1-(benzylamino)pent-4-ene-2,3-diol

: 163592-87-8
(2R,3S,4R)-N-benzyl-3-hydroxy-2-(4-methoxybenzyl)-4-<(tert-butyldimethylsilyl)oxy>pyrrolidine

Guidance literature:: Multi-step reaction with 10 steps

1: aq. NaHCO₃ / acetone / 3 h / Ambient temperature

2: 91.1 percent / PTS, NaHCO₃ / CH₂Cl₂

3: 74.9 percent / water, K₃Fe(CN)6, K₂CO₃, OsO₄ / 2-methyl-propan-2-ol / Ambient temperature

4: Et₃N / CH₂Cl₂ / 0 °C

5: K₂CO₃ / methanol / 0.33 h

6: 85.2 percent / CuI / tetrahydrofuran / -10 °C

7: DIBAL / toluene / 3 h / -78 °C

8: PPh₃, DEAD / CH₂Cl₂ / Ambient temperature

9: 80 percent / 2N aq. HCl / tetrahydrofuran

10: 89 percent / imidazole / dimethylformamide / 0.83 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; copper(l) iodide; osmium(VIII) oxide; water; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; triphenylphosphine; potassium hexacyanoferrate(III); diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;