(S)-benzyl 3-((S)-2-amino-2-cyclohexylacetamido)piperidine-1-carboxylate hydrochloride

Base Information

• Chemical Name: (S)-benzyl 3-((S)-2-amino-2-cyclohexylacetamido)piperidine-1-carboxylate hydrochloride
• CAS No.: 1361322-98-6
• Molecular Formula: C₂₁H₃₁N₃O₃*ClH
• Molecular Weight: 409.956
• Mol file: 1361322-98-6.mol

Synonyms:(S)-benzyl 3-((S)-2-amino-2-cyclohexylacetamido)piperidine-1-carboxylate hydrochloride

Chemical Property of (S)-benzyl 3-((S)-2-amino-2-cyclohexylacetamido)piperidine-1-carboxylate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-benzyl 3-((S)-2-amino-2-cyclohexylacetamido)piperidine-1-carboxylate hydrochloride

There total 5 articles about (S)-benzyl 3-((S)-2-amino-2-cyclohexylacetamido)piperidine-1-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-benzyl 3-((S)-2-(tert-butoxycarbonylamino)-2-cyclohexylacetamido)piperidine-1-carboxylate (1361322-97-5) → (S)-benzyl 3-((S)-2-amino-2-cyclohexylacetamido)piperidine-1-carboxylate hydrochloride (1361322-98-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

benzyl (3S)-3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate (876379-22-5) → (S)-benzyl 3-((S)-2-amino-2-cyclohexylacetamido)piperidine-1-carboxylate hydrochloride (1361322-98-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h / 0 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

(S)-benzyl 3-aminopiperidine-1-carboxylate hydrochloride (876461-55-1) → (S)-benzyl 3-((S)-2-amino-2-cyclohexylacetamido)piperidine-1-carboxylate hydrochloride (1361322-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 0 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.12.109

upstream raw materials:

benzyl (3S)-3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate

(S)-benzyl 3-aminopiperidine-1-carboxylate hydrochloride

(S)-benzyl 3-((S)-2-(tert-butoxycarbonylamino)-2-cyclohexylacetamido)piperidine-1-carboxylate

benzyl chloroformate

Downstream raw materials:

tert-butyl (S)-1-((S)-1-cyclohexyl-2-oxo-2-((S)-piperidin-3-ylamino)ethylamino)-1-oxopropan-2-yl(methyl)carbamate

(S)-N-((S)-2-((S)-1-benzylpiperidin-3-ylamino)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide

(S)-N-((S)-1-cyclohexyl-2-oxo-2-((S)-1-(3-phenylpropyl)piperidin-3-ylamino)ethyl)-2-(methylamino)propanamide

tert-butyl (S)-1-((S)-2-((S)-1-benzoylpiperidin-3-ylamino)-1-cyclohexyl-2-oxoethylamino)-1-oxopropan-2-yl(methyl)carbamate