N-(2-(N',N'-dimethylamino)ethyl)-3-(4-phenyl-1,2,3-triazol-1-yl)-1,8-naphthalimide

Base Information

• Chemical Name: N-(2-(N',N'-dimethylamino)ethyl)-3-(4-phenyl-1,2,3-triazol-1-yl)-1,8-naphthalimide
• CAS No.: 1073775-52-6
• Molecular Formula: C₂₄H₂₁N₅O₂
• Molecular Weight: 411.463
• Mol file: 1073775-52-6.mol

Synonyms:N-(2-(N',N'-dimethylamino)ethyl)-3-(4-phenyl-1,2,3-triazol-1-yl)-1,8-naphthalimide

Chemical Property of N-(2-(N',N'-dimethylamino)ethyl)-3-(4-phenyl-1,2,3-triazol-1-yl)-1,8-naphthalimide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(N',N'-dimethylamino)ethyl)-3-(4-phenyl-1,2,3-triazol-1-yl)-1,8-naphthalimide

There total 4 articles about N-(2-(N',N'-dimethylamino)ethyl)-3-(4-phenyl-1,2,3-triazol-1-yl)-1,8-naphthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-(4-phenyl-1,2,3-triazol-1-yl)-1,8-naphthalic anhydride (1073775-49-1) + N,N-dimethylethylenediamine (108-00-9) → N-(2-(N',N'-dimethylamino)ethyl)-3-(4-phenyl-1,2,3-triazol-1-yl)-1,8-naphthalimide (1073775-52-6)

Guidance literature:

In ethanol; Reflux;

DOI:10.1016/j.tet.2011.01.063

Reference yield:

3-azido-1,8-naphthalic anhydride (1073775-48-0) → N-(2-(N',N'-dimethylamino)ethyl)-3-(4-phenyl-1,2,3-triazol-1-yl)-1,8-naphthalimide (1073775-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 8 h / 20 °C / Darkness

2: ethanol / Reflux

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In ethanol; water; tert-butyl alcohol;

DOI:10.1016/j.tet.2011.01.063

Reference yield:

3-amino-naphthalene-1,8-dicarboxylic acid-anhydride (23204-38-8) → N-(2-(N',N'-dimethylamino)ethyl)-3-(4-phenyl-1,2,3-triazol-1-yl)-1,8-naphthalimide (1073775-52-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; acetic acid; sodium nitrite / water / 1.33 h / 0 - 5 °C

1.2: 2.5 h / 0 - 20 °C

2.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 8 h / 20 °C / Darkness

3.1: ethanol / Reflux

With hydrogenchloride; copper(ll) sulfate pentahydrate; acetic acid; sodium L-ascorbate; sodium nitrite; In ethanol; water; tert-butyl alcohol;

DOI:10.1016/j.tet.2011.01.063

upstream raw materials:

3-(4-phenyl-1,2,3-triazol-1-yl)-1,8-naphthalic anhydride

N,N-dimethylethylenediamine

3-azido-1,8-naphthalic anhydride

3-amino-naphthalene-1,8-dicarboxylic acid-anhydride