(tetrahydro-pyran-4-yl)-[3-(3-trifluoromethoxy-phenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl]-amine

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Chemical Name:(tetrahydro-pyran-4-yl)-[3-(3-trifluoromethoxy-phenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl]-amine
CAS No.:1331741-81-1
Molecular Formula:C₁₇H₁₆F₃N₅O₂
Molecular Weight:379.342
Hs Code.:

Synonyms:(tetrahydro-pyran-4-yl)-[3-(3-trifluoromethoxy-phenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl]-amine

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Chemical Property of (tetrahydro-pyran-4-yl)-[3-(3-trifluoromethoxy-phenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl]-amine

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Technology Process of (tetrahydro-pyran-4-yl)-[3-(3-trifluoromethoxy-phenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl]-amine

There total 6 articles about (tetrahydro-pyran-4-yl)-[3-(3-trifluoromethoxy-phenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1331742-80-3
5-chloro-3-(3-trifluoromethoxy-phenyl)-3H-[1,2,3]triazolo[4,5-b]pyridine

: 33024-60-1
tetrahydro-2H-pyran-4-ylamine monohydrochloride

: 1331741-81-1
(tetrahydro-pyran-4-yl)-[3-(3-trifluoromethoxy-phenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl]-amine

Guidance literature:: With triethylamine; In acetonitrile; at 150 ℃; for 4h; Microwave irradiation;

Reference yield:

: 16013-85-7,136901-10-5
2,6-dicholoro-3-nitropyridine

: 1331741-81-1
(tetrahydro-pyran-4-yl)-[3-(3-trifluoromethoxy-phenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / ethanol / 504 h / 20 °C

2: hydrogen / Ni-Raney / ethyl acetate; ethanol / 30 °C / 37503.8 Torr

3: sodium nitrite; acetic acid / 2 h / 20 °C

4: triethylamine / acetonitrile / 4 h / 150 °C / Microwave irradiation

With hydrogen; sodium hydrogencarbonate; acetic acid; triethylamine; sodium nitrite; Ni-Raney; In ethanol; ethyl acetate; acetonitrile;

Reference yield:

: 1535-73-5
m-trifluoromethoxyaniline

: 1331741-81-1
(tetrahydro-pyran-4-yl)-[3-(3-trifluoromethoxy-phenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / ethanol / 504 h / 20 °C

2: hydrogen / Ni-Raney / ethyl acetate; ethanol / 30 °C / 37503.8 Torr

3: sodium nitrite; acetic acid / 2 h / 20 °C

4: triethylamine / acetonitrile / 4 h / 150 °C / Microwave irradiation

With hydrogen; sodium hydrogencarbonate; acetic acid; triethylamine; sodium nitrite; Ni-Raney; In ethanol; ethyl acetate; acetonitrile;