2-bromo-1-(bromomethyl)-4-nitrobenzene

Base Information

• Chemical Name: 2-bromo-1-(bromomethyl)-4-nitrobenzene
• CAS No.: 940-05-6
• Molecular Formula: C7H5 Br2 N O2
• Molecular Weight: 294.93
• Hs Code.: 2904909090
• Mol file: 940-05-6.mol

Synonyms:Toluene, a,2-dibromo-4-nitro- (7CI,8CI);2-Bromo-1-(bromomethyl)-4-nitrobenzene; 2-Bromo-4-nitrobenzyl bromide

Chemical Property of 2-bromo-1-(bromomethyl)-4-nitrobenzene

Chemical Property:

• Vapor Pressure: 0.000104mmHg at 25°C
• Melting Point: 73-74°
• Refractive Index: 1.642
• Boiling Point: 348°Cat760mmHg
• Flash Point: 164.3°C
• PSA: 45.82000
• Density: 2.006g/cm³
• LogP: 3.77540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-4-nitrobenzyl bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-1-(bromomethyl)-4-nitrobenzene

There total 4 articles about 2-bromo-1-(bromomethyl)-4-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-bromo-4-nitrotoluene (7745-93-9) → 2-bromo-1-(bromomethyl)-4-nitrobenzene (940-05-6)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; at 80 ℃; for 7h; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.201100739

Reference yield: 38.0%

2-bromo-4-nitrotoluene (7745-93-9) → 2-bromo-1-dibromomethyl-4-nitrobenzene (1313762-48-9) + 2-bromo-1-(bromomethyl)-4-nitrobenzene (940-05-6)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In benzene; for 16h; Reflux;

DOI:10.1016/j.tetlet.2015.10.091

Reference yield: 33.0%

m-nitrobromobenzene (585-79-5) → 2-bromo-1-(bromomethyl)-4-nitrobenzene (940-05-6)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 70 ℃; for 3h;

upstream raw materials:

2-bromo-4-nitrotoluene

m-nitrobromobenzene

Downstream raw materials:

2-Acetylamino-N-(2-bromo-4-nitrobenzyl)aniline

2-Brom-4-nitro-benzylacetylamino-malonester

1-(2-bromo-4-nitro-benzyl)-4-methyl-piperazine

2-bromo-4-nitro-benzaldehyde

Refernces

• 1、 -. "ABELSON NON-TYROSINE KINASE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES". Page/Page column 22-23. . Retrieved 2020/10/28.
• 2、 Gabriele, Bartolo,Veltri, Lucia,Maltese, Vito,Spina, Rosella,Mancuso, Raffaella,Salerno, Giuseppe. "Versatile synthesis of isoquinolines and isochromenes by Pd-catalyzed oxidative carbonylation of (2-alkynyl)benzylideneamine derivatives". experimental part. p. 5626 - 5635. Retrieved 2011/11/29.