2-bromo-1-dibromomethyl-4-nitrobenzene

Base Information

• Chemical Name: 2-bromo-1-dibromomethyl-4-nitrobenzene
• CAS No.: 1313762-48-9
• Molecular Formula: C₇H₄Br₃NO₂
• Molecular Weight: 373.826
• Mol file: 1313762-48-9.mol

Synonyms:

Chemical Property of 2-bromo-1-dibromomethyl-4-nitrobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-1-dibromomethyl-4-nitrobenzene

There total 2 articles about 2-bromo-1-dibromomethyl-4-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

2-bromo-4-nitrotoluene (7745-93-9) → 2-bromo-1-dibromomethyl-4-nitrobenzene (1313762-48-9) + 2-bromo-1-(bromomethyl)-4-nitrobenzene (940-05-6)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In benzene; for 16h; Reflux;

DOI:10.1016/j.tetlet.2015.10.091

Reference yield: 27.0%

2-bromo-4-nitrotoluene (7745-93-9) → 2-bromo-1-dibromomethyl-4-nitrobenzene (1313762-48-9)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In benzene; for 16h; Reflux; Inert atmosphere;

DOI:10.1039/c1cc10683j

Reference yield:

2-bromo-1-dibromomethyl-4-nitrobenzene (1313762-48-9) → 4-nitro-2-vinylbenzaldehyde (1313762-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 3 h / 60 °C / Inert atmosphere

2: caesium carbonate; triphenylphosphine; palladium dichloride / tetrahydrofuran; water / 22 h / 85 °C / sealed tube; Inert atmosphere

With sulfuric acid; caesium carbonate; triphenylphosphine; palladium dichloride; In tetrahydrofuran; water;

DOI:10.1039/c1cc10683j

upstream raw materials:

2-bromo-4-nitrotoluene

Downstream raw materials:

4-nitro-2-vinylbenzaldehyde

5-nitro-2,3-dihydroinden-1-one

Refernces

• 1、 Vautravers, Nicolas R.,Regent, Damien D.,Breit, Bernhard. "Inter- and intramolecular hydroacylation of alkenes employing a bifunctional catalyst system". supporting information; experimental part. p. 6635 - 6637. Retrieved 2011/06/27.