tert-butyl 1-{[((1R)-1-{5-[3,5-dichloro-2-(2,2-difluoroethoxy)phenyl]-3-fluoropyridin-2-yl}ethyl)amino]carbonyl}cyclopropyl carbamate

Base Information

Chemical Name:tert-butyl 1-{[((1R)-1-{5-[3,5-dichloro-2-(2,2-difluoroethoxy)phenyl]-3-fluoropyridin-2-yl}ethyl)amino]carbonyl}cyclopropyl carbamate
CAS No.:864642-89-7
Molecular Formula:C₂₄H₂₆Cl₂F₃N₃O₄
Molecular Weight:548.389
Hs Code.:

Synonyms:tert-butyl 1-{[((1R)-1-{5-[3,5-dichloro-2-(2,2-difluoroethoxy)phenyl]-3-fluoropyridin-2-yl}ethyl)amino]carbonyl}cyclopropyl carbamate

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Chemical Property of tert-butyl 1-{[((1R)-1-{5-[3,5-dichloro-2-(2,2-difluoroethoxy)phenyl]-3-fluoropyridin-2-yl}ethyl)amino]carbonyl}cyclopropyl carbamate

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Technology Process of tert-butyl 1-{[((1R)-1-{5-[3,5-dichloro-2-(2,2-difluoroethoxy)phenyl]-3-fluoropyridin-2-yl}ethyl)amino]carbonyl}cyclopropyl carbamate

There total 2 articles about tert-butyl 1-{[((1R)-1-{5-[3,5-dichloro-2-(2,2-difluoroethoxy)phenyl]-3-fluoropyridin-2-yl}ethyl)amino]carbonyl}cyclopropyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[(1R)-1-ammonioethyl]-5-[3,5-dichloro-2-(2,2-difluoroethoxy)phenyl]-3-fluoropyridinium dichloride

: 88950-64-5
1-<(tert-butyloxy)carbonylamino>cyclopropane-1-carboxylic acid

: 864642-89-7
tert-butyl 1-{[((1R)-1-{5-[3,5-dichloro-2-(2,2-difluoroethoxy)phenyl]-3-fluoropyridin-2-yl}ethyl)amino]carbonyl}cyclopropyl carbamate

Guidance literature:: 2-[(1R)-1-ammonioethyl]-5-[3,5-dichloro-2-(2,2-difluoroethoxy)phenyl]-3-fluoropyridinium dichloride; 1-<(tert-butyloxy)carbonylamino>cyclopropane-1-carboxylic acid; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 0.166667h;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.333333h; pH=8;

Reference yield:

: 864710-29-2
((1R)-1-{5-[3,5-dichloro-2-(2,2-difluoroethoxy)phenyl]-3-fluoropyridin-2-yl}ethyl)amine

: 88950-64-5
1-<(tert-butyloxy)carbonylamino>cyclopropane-1-carboxylic acid

: 864642-89-7
tert-butyl 1-{[((1R)-1-{5-[3,5-dichloro-2-(2,2-difluoroethoxy)phenyl]-3-fluoropyridin-2-yl}ethyl)amino]carbonyl}cyclopropyl carbamate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; TEA; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.11.057