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88950-64-5

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88950-64-5 Usage

Description

1-(Boc-amino)cyclopropanecarboxylic acid is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is characterized by the presence of a cyclopropane ring, an amino group protected by a Boc (tert-butyloxycarbonyl) group, and a carboxylic acid functional group. This unique structure allows it to be a versatile building block in the development of new therapeutic agents.

Uses

Used in Pharmaceutical Synthesis:
1-(Boc-amino)cyclopropanecarboxylic acid is used as a reagent in the synthesis of pyrrolotriazinone derivatives, which are therapeutic PI3K inhibitors. These inhibitors play a crucial role in the regulation of cellular processes such as cell growth, survival, and metabolism, making them potential targets for the treatment of various diseases, including cancer.
Used in Antitumor Agent Development:
1-(Boc-amino)cyclopropanecarboxylic acid is also used as a reagent in the synthesis of ether, carbamate, and ester derivatives of adarotene, which are potential antitumor agents. Adarotene is a compound with significant antitumor activity, and its derivatives may offer improved potency, selectivity, and reduced side effects in cancer treatment.

Check Digit Verification of cas no

The CAS Registry Mumber 88950-64-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,9,5 and 0 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 88950-64:
(7*8)+(6*8)+(5*9)+(4*5)+(3*0)+(2*6)+(1*4)=185
185 % 10 = 5
So 88950-64-5 is a valid CAS Registry Number.

88950-64-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
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  • Alfa Aesar

  • (H61992)  1-(Boc-amino)cyclopropanecarboxylic acid, 98%   

  • 88950-64-5

  • 250mg

  • 819.0CNY

  • Detail
  • Alfa Aesar

  • (H61992)  1-(Boc-amino)cyclopropanecarboxylic acid, 98%   

  • 88950-64-5

  • 1g

  • 2950.0CNY

  • Detail
  • Aldrich

  • (39977)  1-(Boc-amino)cyclopropanecarboxylicacid  ≥98.0% (TLC)

  • 88950-64-5

  • 39977-1G-F

  • 4,502.16CNY

  • Detail

88950-64-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(Boc-amino)cyclopropanecarboxylic acid

1.2 Other means of identification

Product number -
Other names 1-[(2-methylpropan-2-yl)oxycarbonylamino]cyclopropane-1-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:88950-64-5 SDS

88950-64-5Relevant articles and documents

SUBSTITUTED TRIAZINONES AS THYROID HORMONE RECEPTOR AGONISTS

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Paragraph 00269-00270, (2021/07/24)

The application relates to a compound of Formula (I') or (I), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of thyroid hormone receptors, a pharmaceutical composition comprising a compound of Formula (I') or (I), and a method of treating or preventing a disease or disorder regulated by thyroid hormone.

Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1

Maben, Zachary,Arya, Richa,Rane, Digamber,An, W. Frank,Metkar, Shailesh,Hickey, Marc,Bender, Samantha,Ali, Akbar,Nguyen, Tina T.,Evnouchidou, Irini,Schilling, Roger,Stratikos, Efstratios,Golden, Jennifer,Stern, Lawrence J.

, p. 103 - 121 (2020/02/20)

ERAP1 is an endoplasmic reticulum-resident zinc aminopeptidase that plays an important role in the immune system by trimming peptides for loading onto major histocompatibility complex proteins. Here, we report discovery of the first inhibitors selective for ERAP1 over its paralogues ERAP2 and IRAP. Compound 1 (N-(N-(2-(1H-indol-3-yl)ethyl)carbamimidoyl)-2,5-difluorobenzenesulfonamide) and compound 2 (1-(1-(4-acetylpiperazine-1-carbonyl)cyclohexyl)-3-(p-tolyl)urea) are competitive inhibitors of ERAP1 aminopeptidase activity. Compound 3 (4-methoxy-3-(N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)sulfamoyl)benzoic acid) allosterically activates ERAP1's hydrolysis of fluorogenic and chromogenic amino acid substrates but competitively inhibits its activity toward a nonamer peptide representative of physiological substrates. Compounds 2 and 3 inhibit antigen presentation in a cellular assay. Compound 3 displays higher potency for an ERAP1 variant associated with increased risk of autoimmune disease. These inhibitors provide mechanistic insights into the determinants of specificity for ERAP1, ERAP2, and IRAP and offer a new therapeutic approach of specifically inhibiting ERAP1 activity in vivo.

A 4, 7 - diaza spiro [2.5] octane -7 - formic acid tert-butyl synthetic method

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Paragraph 0033; 0041; 0042; 0060, (2019/01/08)

The invention belongs to the technical field of chemical synthesis of N-heterocycle-containing drug intermediates, and particularly relates to a synthesis method of tert-butyl 4,7-diazaspiro[2.5]octyl-7-formate. By using diethyl malonate as a raw material, cyclization reaction, Hofmann reaction, hydrolysis reaction, acylation reaction for recyclization, reduction reaction and the like are performed to conveniently synthesize the target compound product. The method has the advantages of simple synthesis technique, cheap and accessible raw materials, mild reaction conditions, high controllability, low cost and high yield, and is convenient to operate.

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