2-methoxy-7-(3,5-di-O-toluoyl-2-deoxy-β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-4-ylamine

Base Information

• Chemical Name: 2-methoxy-7-(3,5-di-O-toluoyl-2-deoxy-β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-4-ylamine
• CAS No.: 698376-41-9
• Molecular Formula: C₂₈H₂₈N₄O₆
• Molecular Weight: 516.554
• Mol file: 698376-41-9.mol

Synonyms:2-methoxy-7-(3,5-di-O-toluoyl-2-deoxy-β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-4-ylamine

Chemical Property of 2-methoxy-7-(3,5-di-O-toluoyl-2-deoxy-β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-4-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-methoxy-7-(3,5-di-O-toluoyl-2-deoxy-β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-4-ylamine

There total 1 articles about 2-methoxy-7-(3,5-di-O-toluoyl-2-deoxy-β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride (4330-21-6) + 4-amino-2-methoxy-7H-pyrrolo<2,3-d>pyrimidine (100383-13-9) → 2-methoxy-7-(3,5-di-O-toluoyl-2-deoxy-β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-4-ylamine (698376-41-9)

Guidance literature:

With sodium hydride; In acetonitrile; at 20 ℃;

DOI:10.1021/jo0497959

Reference yield: 86.0%

2-methoxy-7-(3,5-di-O-toluoyl-2-deoxy-β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-4-ylamine (698376-41-9) → 4-amino-7-(3,5-di-O-toluoyl-2-deoxy-β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-2(3H)-one (698376-58-8)

Guidance literature:

With thiophenol; In ethylene glycol; at 100 - 120 ℃;

DOI:10.1021/jo0497959

Reference yield:

2-methoxy-7-(3,5-di-O-toluoyl-2-deoxy-β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-4-ylamine (698376-41-9) → 4-(N,N-diisobutyl-formamidino)-7-(3,5-di-O-toluoyl-2-deoxy-β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-2(3H)-one

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / PhSH / ethane-1,2-diol / 100 - 120 °C

2: 73 percent / diisobutylformamide / CH₂Cl₂ / 20 °C

With N-isobutyl-3-methylbutanamide; thiophenol; In dichloromethane; ethylene glycol;

DOI:10.1021/jo0497959

upstream raw materials:

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

4-amino-2-methoxy-7H-pyrrolo<2,3-d>pyrimidine

Downstream raw materials:

4-amino-7-(3,5-di-O-toluoyl-2-deoxy-β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-2(3H)-one