(Z,3S,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylideneethyl]diphenylphosphine oxide

Base Information

Chemical Name:(Z,3S,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylideneethyl]diphenylphosphine oxide
CAS No.:215929-37-6
Molecular Formula:C₃₃H₅₁O₃PSi₂
Molecular Weight:582.911
Hs Code.:

Synonyms:(Z,3S,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylideneethyl]diphenylphosphine oxide

Suppliers and Price of (Z,3S,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylideneethyl]diphenylphosphine oxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (Z,3S,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylideneethyl]diphenylphosphine oxide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (Z,3S,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylideneethyl]diphenylphosphine oxide

There total 5 articles about (Z,3S,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylideneethyl]diphenylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.4%

: C₂₇H₃₇O₃PSi

: 18162-48-6
tert-butyldimethylsilyl chloride

: 215929-37-6
(Z,3S,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylideneethyl]diphenylphosphine oxide

Guidance literature:: With 1H-imidazole; In dichloromethane; at 30 ℃; for 6h; Reagent/catalyst; Temperature;

Reference yield:

: methyl (Z,3S,5RS)-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylidene]acetate

: 215929-37-6
(Z,3S,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylideneethyl]diphenylphosphine oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 40 percent / DIBAL / toluene; CH₂Cl₂ / 0.5 h / -78 °C

2.1: 91 percent / N-chlorosuccinimide; dimethyl sulfide / CH₂Cl₂ / -20 - 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -50 °C

3.2: 72 percent / aq. H₂O₂ / CHCl₃; tetrahydrofuran / 1.5 h / 20 °C

With N-chloro-succinimide; n-butyllithium; dimethylsulfide; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; toluene; 2.1: chlorination / 3.2: oxidation;
DOI:10.1016/S0968-0896(00)00259-5

Reference yield:

: 215929-41-2
(Z,3S,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylidene]ethanol

: 215929-37-6
(Z,3S,5S)-2-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylideneethyl]diphenylphosphine oxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 91 percent / N-chlorosuccinimide; dimethyl sulfide / CH₂Cl₂ / -20 - 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -50 °C

2.2: 72 percent / aq. H₂O₂ / CHCl₃; tetrahydrofuran / 1.5 h / 20 °C

With N-chloro-succinimide; n-butyllithium; dimethylsulfide; In tetrahydrofuran; hexane; dichloromethane; 1.1: chlorination / 2.2: oxidation;
DOI:10.1016/S0968-0896(00)00259-5