9-[4-(1-amino-cyclobutyl)-phenyl]-8-phenyl-9H-purine-2-carboxylic acid methyl-amide

Base Information

Chemical Name:9-[4-(1-amino-cyclobutyl)-phenyl]-8-phenyl-9H-purine-2-carboxylic acid methyl-amide
CAS No.:1439392-11-6
Molecular Formula:C₂₃H₂₂N₆O
Molecular Weight:398.467
Hs Code.:

Synonyms:9-[4-(1-amino-cyclobutyl)-phenyl]-8-phenyl-9H-purine-2-carboxylic acid methyl-amide

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Chemical Property of 9-[4-(1-amino-cyclobutyl)-phenyl]-8-phenyl-9H-purine-2-carboxylic acid methyl-amide

Chemical Property:

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Technology Process of 9-[4-(1-amino-cyclobutyl)-phenyl]-8-phenyl-9H-purine-2-carboxylic acid methyl-amide

There total 5 articles about 9-[4-(1-amino-cyclobutyl)-phenyl]-8-phenyl-9H-purine-2-carboxylic acid methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439392-13-8
{1-[4-(2-methylcarbamoyl-8-phenyl-purin-9-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

: 1439392-11-6
9-[4-(1-amino-cyclobutyl)-phenyl]-8-phenyl-9H-purine-2-carboxylic acid methyl-amide

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1439391-55-5
{1-[4-(2-chloro-8-phenyl-purin-9-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

: 1439392-11-6
9-[4-(1-amino-cyclobutyl)-phenyl]-8-phenyl-9H-purine-2-carboxylic acid methyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; sodium carbonate / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

2: hydrogenchloride / ethyl acetate / 4 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; palladium diacetate; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1259224-00-4
[1-(4-amino-phenyl)-cyclobutyl]-carbamic acid tert-butyl ester

: 1439392-11-6
9-[4-(1-amino-cyclobutyl)-phenyl]-8-phenyl-9H-purine-2-carboxylic acid methyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2: hydrogen / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3: copper diacetate / 2 h / 100 °C / Inert atmosphere

4: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; sodium carbonate / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

5: hydrogenchloride / ethyl acetate / 4 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; hydrogen; copper diacetate; palladium diacetate; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;