N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-N-(propan-2-yl)-2-(2H-1,2,3-triazol-2-yl)benzamide

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Chemical Name:N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-N-(propan-2-yl)-2-(2H-1,2,3-triazol-2-yl)benzamide
CAS No.:1381970-89-3
Molecular Formula:C₂₃H₂₄FN₇O
Molecular Weight:433.488
Hs Code.:

Synonyms:N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-N-(propan-2-yl)-2-(2H-1,2,3-triazol-2-yl)benzamide

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Chemical Property of N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-N-(propan-2-yl)-2-(2H-1,2,3-triazol-2-yl)benzamide

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Technology Process of N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-N-(propan-2-yl)-2-(2H-1,2,3-triazol-2-yl)benzamide

There total 6 articles about N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-N-(propan-2-yl)-2-(2H-1,2,3-triazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 75-30-9
2-iodo-propane

: 1381970-61-1
N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

: 1381970-89-3
N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-N-(propan-2-yl)-2-(2H-1,2,3-triazol-2-yl)benzamide

Guidance literature:: N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

2-iodo-propane; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2015.01.044

Reference yield:

: 1381971-88-5
tert-butyl {2-[3-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}carbamate

: 1381970-89-3
N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-N-(propan-2-yl)-2-(2H-1,2,3-triazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethyl acetate / 15 h / 20 °C

2.1: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

3.2: 3 h / 20 °C

With hydrogenchloride; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; sodium hydride; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2015.01.044

Reference yield:

: 1381971-84-1
5-fluoro-2-[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl]pyridine

: 1381970-89-3
N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-N-(propan-2-yl)-2-(2H-1,2,3-triazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethyl acetate; methanol / 5 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

3.1: hydrogenchloride / ethyl acetate / 15 h / 20 °C

4.1: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

5.2: 3 h / 20 °C

With hydrogenchloride; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2015.01.044