(2R,6R,7S)-6-Benzyloxy-2-[(2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-ylmethyl]-7-(3-benzyloxy-propyl)-7-methyl-oxepan-3-one

Base Information

Chemical Name:(2R,6R,7S)-6-Benzyloxy-2-[(2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-ylmethyl]-7-(3-benzyloxy-propyl)-7-methyl-oxepan-3-one
CAS No.:436153-73-0
Molecular Formula:C₅₁H₆₈O₈Si
Molecular Weight:837.182
Hs Code.:

(2R,6R,7S)-6-Benzyloxy-2-[(2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-ylmethyl]-7-(3-benzyloxy-propyl)-7-methyl-oxepan-3-one

Synonyms:(2R,6R,7S)-6-Benzyloxy-2-[(2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-ylmethyl]-7-(3-benzyloxy-propyl)-7-methyl-oxepan-3-one

Suppliers and Price of (2R,6R,7S)-6-Benzyloxy-2-[(2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-ylmethyl]-7-(3-benzyloxy-propyl)-7-methyl-oxepan-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,6R,7S)-6-Benzyloxy-2-[(2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-ylmethyl]-7-(3-benzyloxy-propyl)-7-methyl-oxepan-3-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2R,6R,7S)-6-Benzyloxy-2-[(2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-ylmethyl]-7-(3-benzyloxy-propyl)-7-methyl-oxepan-3-one

There total 28 articles about (2R,6R,7S)-6-Benzyloxy-2-[(2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-ylmethyl]-7-(3-benzyloxy-propyl)-7-methyl-oxepan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 436153-72-9
(2R,3S,6R,7S)-6-Benzyloxy-2-[(2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-ylmethyl]-7-(3-benzyloxy-propyl)-7-methyl-oxepan-3-ol

: 436153-73-0
(2R,6R,7S)-6-Benzyloxy-2-[(2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-ylmethyl]-7-(3-benzyloxy-propyl)-7-methyl-oxepan-3-one

Guidance literature:: With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In acetonitrile; at 20 ℃; for 6.5h;
DOI:10.1021/ol025814u

Reference yield: 48.0%

: 436153-87-6
(2S,6R,7S)-6-Benzyloxy-2-[(2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-ylmethyl]-7-(3-benzyloxy-propyl)-7-methyl-oxepan-3-one

: 436153-73-0
(2R,6R,7S)-6-Benzyloxy-2-[(2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-ylmethyl]-7-(3-benzyloxy-propyl)-7-methyl-oxepan-3-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 110 ℃;
DOI:10.1021/ol025814u

Reference yield:

: (5R,6S)-5,9-Bis-benzyloxy-6-methoxymethoxy-6-methyl-nonanal

: 436153-73-0
(2R,6R,7S)-6-Benzyloxy-2-[(2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-ylmethyl]-7-(3-benzyloxy-propyl)-7-methyl-oxepan-3-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: 2-methyl-2-butene; NaH₂PO₄; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 1 h / 20 °C

2.1: 3.02 g / trifluoroacetic acid / CH₂Cl₂ / 0 - 20 °C

3.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 2 h / 20 °C

3.2: 62 percent / 4-(dimethylamino)pyridine / toluene / Heating

4.1: potassium hexamethyldisilazanide; hexamethylphosphortriamide / tetrahydrofuran; toluene / 0.5 h / -78 °C

5.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 4 h / 20 °C

5.2: Cs₂CO₃ / PdCl₂(dppf)*CH₂Cl₂ / dimethylformamide; H₂O / 16 h / 50 °C

5.3: 86 percent / aq. NAOH; H₂O₂ / tetrahydrofuran / 0 - 20 °C

6.1: BH₃*THF / tetrahydrofuran / 0 °C

6.2: 37 percent / sodium hydroxide; hydrogen peroxide / H₂O; tetrahydrofuran / 0.5 h / 20 °C

7.1: 92 percent / tetrapropylammonium perruthenate; 4-methylmorpholine 4-oxide / CH₂Cl₂ / 1 h / 20 °C

8.1: 48 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 110 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium chlorite; sodium dihydrogenphosphate; tetrapropylammonium perruthennate; borane-THF; 2-methyl-but-2-ene; 2,4,6-trichlorobenzoyl chloride; potassium hexamethylsilazane; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 9-bora-bicyclo[3.3.1]nonane; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; toluene; tert-butyl alcohol; 5.2: Suzuki-Miyaura coupling;
DOI:10.1021/ol025814u