[4-(4-Fluoro-phenyl)-2,6-diisopropyl-5-((E)-pent-1-enyl)-pyridin-3-yl]-methanol

Base Information

Chemical Name:[4-(4-Fluoro-phenyl)-2,6-diisopropyl-5-((E)-pent-1-enyl)-pyridin-3-yl]-methanol
CAS No.:202857-40-7
Molecular Formula:C₂₃H₃₀FNO
Molecular Weight:355.496
Hs Code.:

Synonyms:[4-(4-Fluoro-phenyl)-2,6-diisopropyl-5-((E)-pent-1-enyl)-pyridin-3-yl]-methanol

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Chemical Property of [4-(4-Fluoro-phenyl)-2,6-diisopropyl-5-((E)-pent-1-enyl)-pyridin-3-yl]-methanol

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Technology Process of [4-(4-Fluoro-phenyl)-2,6-diisopropyl-5-((E)-pent-1-enyl)-pyridin-3-yl]-methanol

There total 6 articles about [4-(4-Fluoro-phenyl)-2,6-diisopropyl-5-((E)-pent-1-enyl)-pyridin-3-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 202857-39-4
propyltriphenylphosphonium bromide

: 202857-40-7
[4-(4-Fluoro-phenyl)-2,6-diisopropyl-5-((E)-pent-1-enyl)-pyridin-3-yl]-methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1016/S0960-894X(01)00766-1

Reference yield:

: 78168-82-8
ethyl 3-amino-4-methyl-pent-2-enoate

: 202857-40-7
[4-(4-Fluoro-phenyl)-2,6-diisopropyl-5-((E)-pent-1-enyl)-pyridin-3-yl]-methanol

Guidance literature:: Multi-step reaction with 5 steps

1.2: DDQ / CH₂Cl₂

2.1: 67 percent / Red-Al / tetrahydrofuran

3.1: 99 percent / PCC / CH₂Cl₂

4.1: 90 percent / KOtBu / tetrahydrofuran

5.1: 80 percent / LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; potassium tert-butylate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; 4.1: Wittig reaction;
DOI:10.1016/S0960-894X(01)00766-1

Reference yield:

: 7152-15-0
ethyl 4-methyl-3-oxo-pentanoate

: 202857-40-7
[4-(4-Fluoro-phenyl)-2,6-diisopropyl-5-((E)-pent-1-enyl)-pyridin-3-yl]-methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: AcO-NH₄ / cyclohexane

2.2: DDQ / CH₂Cl₂

3.1: 67 percent / Red-Al / tetrahydrofuran

4.1: 99 percent / PCC / CH₂Cl₂

5.1: 90 percent / KOtBu / tetrahydrofuran

6.1: 80 percent / LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; potassium tert-butylate; ammonium acetate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; cyclohexane; 5.1: Wittig reaction;
DOI:10.1016/S0960-894X(01)00766-1