3-phenyl-2-ethylsulfanyl-3,4-dihydrobenzo[g]quinazolin-4-one

Base Information

• Chemical Name: 3-phenyl-2-ethylsulfanyl-3,4-dihydrobenzo[g]quinazolin-4-one
• CAS No.: 21323-40-0
• Molecular Formula: C₂₀H₁₆N₂OS
• Molecular Weight: 332.426
• Mol file: 21323-40-0.mol

Synonyms:3-phenyl-2-ethylsulfanyl-3,4-dihydrobenzo[g]quinazolin-4-one

Chemical Property of 3-phenyl-2-ethylsulfanyl-3,4-dihydrobenzo[g]quinazolin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenyl-2-ethylsulfanyl-3,4-dihydrobenzo[g]quinazolin-4-one

There total 4 articles about 3-phenyl-2-ethylsulfanyl-3,4-dihydrobenzo[g]quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ethyl bromide (74-96-4) + 2,3-dihydro-3-phenyl-2-thioxobenzo[g]quinazolin-4(1H)-one → 3-phenyl-2-ethylsulfanyl-3,4-dihydrobenzo[g]quinazolin-4-one (21323-40-0)

Guidance literature:

2,3-dihydro-3-phenyl-2-thioxobenzo[g]quinazolin-4(1H)-one; With sodium hydride; In acetonitrile; at 20 ℃; for 1.5h;

ethyl bromide; In acetonitrile; at 40 - 50 ℃; for 8h; Heating;

DOI:10.1002/jhet.3623

Reference yield: 72.0%

2,3-dihydro-3-phenyl-2-thioxobenzo[g]quinazolin-4(1H)-one → 3-phenyl-2-ethylsulfanyl-3,4-dihydrobenzo[g]quinazolin-4-one (21323-40-0)

Guidance literature:

2,3-dihydro-3-phenyl-2-thioxobenzo[g]quinazolin-4(1H)-one; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

ethyl halide; In N,N-dimethyl-formamide; at 80 ℃; for 20h;

DOI:10.3987/COM-15-13282

Reference yield:

2-Amino-3-naphthoic acid (5959-52-4) → 3-phenyl-2-ethylsulfanyl-3,4-dihydrobenzo[g]quinazolin-4-one (21323-40-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / N,N-dimethyl-formamide / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 20 h / 80 °C

With potassium carbonate; triethylamine; In N,N-dimethyl-formamide;

DOI:10.3987/COM-15-13282

upstream raw materials:

2-Amino-3-naphthoic acid

phenyl isothiocyanate

ethyl bromide