N-(o-nitrobenzenesulfonyl)-4-hydroxymethyl-5-bromo-6,7-dimethoxyindoline

Base Information

Chemical Name:N-(o-nitrobenzenesulfonyl)-4-hydroxymethyl-5-bromo-6,7-dimethoxyindoline
CAS No.:898530-62-6
Molecular Formula:C₁₇H₁₇BrN₂O₇S
Molecular Weight:473.301
Hs Code.:

Synonyms:N-(o-nitrobenzenesulfonyl)-4-hydroxymethyl-5-bromo-6,7-dimethoxyindoline

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Chemical Property of N-(o-nitrobenzenesulfonyl)-4-hydroxymethyl-5-bromo-6,7-dimethoxyindoline

Chemical Property:

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Technology Process of N-(o-nitrobenzenesulfonyl)-4-hydroxymethyl-5-bromo-6,7-dimethoxyindoline

There total 9 articles about N-(o-nitrobenzenesulfonyl)-4-hydroxymethyl-5-bromo-6,7-dimethoxyindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 898530-61-5
{2-[2-(o-nitrobenzenesulfonyl)aminoethyl]-3,6-dibromo-4,5-dimethoxyphenyl}methanol

: 898530-62-6
N-(o-nitrobenzenesulfonyl)-4-hydroxymethyl-5-bromo-6,7-dimethoxyindoline

Guidance literature:: With copper(l) iodide; cesium acetate; In dimethyl sulfoxide; at 80 ℃; for 24h;
DOI:10.1021/ja0619455

Reference yield:

: 898530-74-0
1-(5,8-dibromo-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinolin-2(1H)-yl)-2,2,2-trifluoroethanone

: 898530-62-6
N-(o-nitrobenzenesulfonyl)-4-hydroxymethyl-5-bromo-6,7-dimethoxyindoline

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / methanol; CH₂Cl₂ / 6 h / 20 °C

2: 18.16 g / manganese oxide / CH₂Cl₂ / 18 h / 20 °C

3: tetrahydrofuran / 1.08 h / 0 - 20 °C

4: aq. sodium bicarbonate / tetrahydrofuran / 0.5 h / 20 °C

5: 425.5 mg / sodium borohydride / methanol / 1 h / 0 - 20 °C

6: copper iodide; cesium acetate / dimethylsulfoxide / 24 h / 80 °C

With manganese oxide; sodium tetrahydroborate; copper(l) iodide; cesium acetate; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ja0619455

Reference yield:

: 898530-59-1
5,8-dibromo-3,4-dihydro-6,7-dimethoxyisoquinoline

: 898530-62-6
N-(o-nitrobenzenesulfonyl)-4-hydroxymethyl-5-bromo-6,7-dimethoxyindoline

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 1.08 h / 0 - 20 °C

2: aq. sodium bicarbonate / tetrahydrofuran / 0.5 h / 20 °C

3: 425.5 mg / sodium borohydride / methanol / 1 h / 0 - 20 °C

4: copper iodide; cesium acetate / dimethylsulfoxide / 24 h / 80 °C

With sodium tetrahydroborate; copper(l) iodide; cesium acetate; sodium hydrogencarbonate; In tetrahydrofuran; methanol; dimethyl sulfoxide;
DOI:10.1021/ja0619455