4-{3-hydroxy-4-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-butyl}-benzoic acid methyl ester

Base Information

• Chemical Name: 4-{3-hydroxy-4-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-butyl}-benzoic acid methyl ester
• CAS No.: 1027424-92-5
• Molecular Formula: C₂₅H₂₃F₃O₇S
• Molecular Weight: 524.515

Synonyms:4-{3-hydroxy-4-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-butyl}-benzoic acid methyl ester

Chemical Property of 4-{3-hydroxy-4-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-butyl}-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-{3-hydroxy-4-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-butyl}-benzoic acid methyl ester

There total 2 articles about 4-{3-hydroxy-4-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-butyl}-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{3-oxo-4-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-butyl}-benzoic acid methyl ester → 4-{3-hydroxy-4-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-butyl}-benzoic acid methyl ester (1027424-92-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 23 ℃; for 0.5h;

DOI:10.1021/jm0103920

Reference yield:

1-(methylsufonyl)-4-fluorobenzene (455-15-2) → 4-{3-hydroxy-4-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-butyl}-benzoic acid methyl ester (1027424-92-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 89 percent / K₂CO₃ / pyridine / 18 h / 120 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: tetrahydrofuran; hexane / 3 h / -78 °C

3.1: NaBH₄ / ethanol / 0.5 h / 23 °C

With sodium tetrahydroborate; n-butyllithium; potassium carbonate; In tetrahydrofuran; pyridine; ethanol; hexane;

DOI:10.1021/jm0103920

Reference yield:

4-{3-hydroxy-4-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-butyl}-benzoic acid methyl ester (1027424-92-5) → 4-{(E)-4-[4-(4-Trifluoromethoxy-phenoxy)-benzenesulfonyl]-but-3-enyl}-benzoic acid methyl ester

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.25h;

DOI:10.1021/jm0103920

upstream raw materials:

1-(methylsufonyl)-4-fluorobenzene

Downstream raw materials:

methyl 4-[3-[formyl(hydroxy)amino]-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)butyl]benzoate

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