Pifithrin-α, p-nitro, cyclic

Base Information

• Chemical Name: Pifithrin-α, p-nitro, cyclic
• CAS No.: 60477-38-5
• Molecular Formula: C₁₅H₁₃N₃O₂S
• Molecular Weight: 299.353
• Mol file: 60477-38-5.mol

Synonyms:2-(4-nitrophenyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole

Chemical Property of Pifithrin-α, p-nitro, cyclic

Chemical Property:

• Melting Point: 233-234 °C(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5))
• PKA: 6.14±0.20(Predicted)
• Density: 1.53±0.1 g/cm3(Predicted)
• Storage Temp.: -20C
• Solubility.: ≤1mg/ml in dimethyl formamide

Purity/Quality:

97% ^*data from raw suppliers

p-Nitro-CyclicPifithrin-α ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: p-nitro-Cyclic Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptisis. Anti-cancer agent.

Technology Process of Pifithrin-α, p-nitro, cyclic

There total 10 articles about Pifithrin-α, p-nitro, cyclic which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide → 2-(4-nitrophenyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole (60477-38-5)

Guidance literature:

With methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2005.01.075

Reference yield: 40.0%

2-Amino-4,5,6,7-tetrahydrobenzothiazole (2933-29-1) + 4-Nitrophenacyl bromide (99-81-0) → 2-(4-nitrophenyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole (60477-38-5)

Guidance literature:

In ethanol; for 1.5h; Reflux;

DOI:10.1016/j.bmc.2011.01.039

Reference yield:

2-Amino-4,5,6,7-tetrahydrobenzothiazole (2933-29-1) → 2-(4-nitrophenyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole (60477-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / toluene / 48 h / 20 °C

2: 55 percent / biological medium / 6 h / 37 °C

With biological medium; In toluene;

DOI:10.1021/jm060318n

upstream raw materials:

2-Amino-4,5,6,7-tetrahydrobenzothiazole

4-Nitrophenacyl bromide

cyclohexanone

2-amino-4,5,6,7-tetrahydrobenzothiazole hydroiodide

Downstream raw materials:

4-(5,6,7,8-tetrahydroimidazo[2,1-b]benzothiazol-2-yl)benzenamine hydrochloride

CF₀₅₄

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 60477-38-5 Pifithrin-α, p-nitro, cyclic

Send

Send

Metric Ton KG G Pound L ML

Send

Send