methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexanecarboxylate

Base Information

Chemical Name:methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexanecarboxylate
CAS No.:1612148-90-9
Molecular Formula:C₂₈H₂₇ClN₄O₄
Molecular Weight:519
Hs Code.:

Synonyms:methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexanecarboxylate

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Chemical Property of methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexanecarboxylate

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Technology Process of methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexanecarboxylate

There total 5 articles about methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1146757-94-9
1-(7-chloroquinolin-4-yl)-5-(2-methoxyphenyl)-1H-pyrazole-3-carboxylic acid

: 37993-32-1
1-amino-cyclohexanecarboxylic acid methyl ester hydrochloride

: 1612148-90-9
methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexanecarboxylate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm5003843

Reference yield: 63.0%

: 1612148-90-9
methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexanecarboxylate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; for 16h; Inert atmosphere;

Reference yield:

: 1612148-75-0
methyl 1-(7-chloroquinolin-4-yl)-5-(2-methoxyphenyl)-1H-pyrazole-3-carboxylate

: 1612148-90-9
methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 16 h / 20 °C / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; lithium hydroxide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm5003843