3-[(1S)-2-[(3S)-3-[(tert-butyldimethylsilyl)oxy]pyrrolidin-1-yl]-1-(methylamino)ethyl]-5-fluorobenzonitrile

Base Information

Chemical Name:3-[(1S)-2-[(3S)-3-[(tert-butyldimethylsilyl)oxy]pyrrolidin-1-yl]-1-(methylamino)ethyl]-5-fluorobenzonitrile
CAS No.:1455472-13-5
Molecular Formula:C₂₀H₃₂FN₃OSi
Molecular Weight:377.577
Hs Code.:

Synonyms:3-[(1S)-2-[(3S)-3-[(tert-butyldimethylsilyl)oxy]pyrrolidin-1-yl]-1-(methylamino)ethyl]-5-fluorobenzonitrile

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Chemical Property of 3-[(1S)-2-[(3S)-3-[(tert-butyldimethylsilyl)oxy]pyrrolidin-1-yl]-1-(methylamino)ethyl]-5-fluorobenzonitrile

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Technology Process of 3-[(1S)-2-[(3S)-3-[(tert-butyldimethylsilyl)oxy]pyrrolidin-1-yl]-1-(methylamino)ethyl]-5-fluorobenzonitrile

There total 5 articles about 3-[(1S)-2-[(3S)-3-[(tert-butyldimethylsilyl)oxy]pyrrolidin-1-yl]-1-(methylamino)ethyl]-5-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1455472-12-4
3-[(1S)-2-[(3S)-3-[(tert-butyldimethylsilyl)oxy]pyrrolidin-1-yl]-1-hydroxyethyl]-5-fluorobenzonitrile

: 124-63-0
methanesulfonyl chloride

: 1455472-13-5
3-[(1S)-2-[(3S)-3-[(tert-butyldimethylsilyl)oxy]pyrrolidin-1-yl]-1-(methylamino)ethyl]-5-fluorobenzonitrile

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1455472-09-9
3-fluoro-5-vinylbenzonitrile

: 1455472-13-5
3-[(1S)-2-[(3S)-3-[(tert-butyldimethylsilyl)oxy]pyrrolidin-1-yl]-1-(methylamino)ethyl]-5-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: AD-mix-α / water; tert-butyl alcohol / 24 h / 20 °C

2.1: chloro-trimethyl-silane; Trimethyl orthoacetate / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2.2: 1.5 h / 0 - 20 °C

3.1: ethanol / 3 h / 80 °C

4.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With Trimethyl orthoacetate; chloro-trimethyl-silane; AD-mix-α; triethylamine; In ethanol; dichloromethane; water; tert-butyl alcohol;

Reference yield:

: 1455472-10-2
(S)-3-(1,2-dihydroxyethyl)-5-fluorobenzonitrile

: 1455472-13-5
3-[(1S)-2-[(3S)-3-[(tert-butyldimethylsilyl)oxy]pyrrolidin-1-yl]-1-(methylamino)ethyl]-5-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane; Trimethyl orthoacetate / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

1.2: 1.5 h / 0 - 20 °C

2.1: ethanol / 3 h / 80 °C

3.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With Trimethyl orthoacetate; chloro-trimethyl-silane; triethylamine; In ethanol; dichloromethane;