Technology Process of 5-(2-((S)-1-(2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamido)-2-(3,5-difluorophenyl)ethyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-3-yl)-2-fluorobenzamide
There total 10 articles about 5-(2-((S)-1-(2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamido)-2-(3,5-difluorophenyl)ethyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-3-yl)-2-fluorobenzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.0833333h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: sodium acetate; acetic acid / Reflux
2: selenium(IV) oxide / 1,2-dimethoxyethane / 20 h / 130 °C
3: copper(II) sulfate / dichloromethane / 2 h / 20 °C
4: copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C
5: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C
6: triethylamine / dichloromethane / 0 °C
7: sodium hydrogencarbonate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 150 °C / Microwave irradiation
8: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C
9: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 0 °C
With
hydrogenchloride; selenium(IV) oxide; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; sodium acetate; copper(II) bis(trifluoromethanesulfonate); sodium hydrogencarbonate; copper(II) sulfate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: sodium acetate; acetic acid / Reflux
2: selenium(IV) oxide / 1,2-dimethoxyethane / 20 h / 130 °C
3: copper(II) sulfate / dichloromethane / 2 h / 20 °C
4: copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C
5: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C
6: triethylamine / dichloromethane / 0 °C
7: sodium hydrogencarbonate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 150 °C / Microwave irradiation
8: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C
9: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 0 °C
With
hydrogenchloride; selenium(IV) oxide; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; sodium acetate; copper(II) bis(trifluoromethanesulfonate); sodium hydrogencarbonate; copper(II) sulfate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;
