4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde

Base Information

• Chemical Name: 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde
• CAS No.: 141667-47-2
• Molecular Formula: C₂₂H₂₁NO₄S₂
• Molecular Weight: 427.545
• Mol file: 141667-47-2.mol

Synonyms:4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde

Chemical Property of 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde

There total 3 articles about 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

3-(4-methylbenzenesulfenyl)-1-(4'-methylbenzenesulfonyl)-2-pyridone (141667-32-5) + acrolein (107-02-8,25068-14-8) → 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde (141667-47-2)

Guidance literature:

In dichloromethane; at 90 ℃; for 120h;

DOI:10.1021/jo00041a010

Reference yield:

3-(4-methylbenzenesulfenyl)-2-pyridone (107383-65-3) → 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde (141667-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) lithium hexamethyldisilazide / 1) THF, hexane, 0 deg C, 2) THF, hexane

2: 42 percent / CH₂Cl₂ / 120 h / 90 °C

With lithium hexamethyldisilazane; In dichloromethane;

DOI:10.1021/jo00041a010

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde (141667-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) lithium hexamethyldisilazide / 1) THF, hexane, 0 deg C, 2) THF, hexane

2: 42 percent / CH₂Cl₂ / 120 h / 90 °C

With lithium hexamethyldisilazane; In dichloromethane;

DOI:10.1021/jo00041a010

upstream raw materials:

3-(4-methylbenzenesulfenyl)-1-(4'-methylbenzenesulfonyl)-2-pyridone

acrolein

3-(4-methylbenzenesulfenyl)-2-pyridone

p-toluenesulfonyl chloride

Downstream raw materials:

5-endo-(hydroxymethyl)-4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

5-endo-<<(tert-butyldimethylsilyl)oxy>methyl>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

methyl <<(tert-butyldimethylsilyl)oxy>methyl>-4β-<(4'-methylbenzenesulfonyl)amino>cyclohexene-1-carboxylate

5-endo-<<(tert-butyldimethylsilyl)oxy>methyl>-4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene