3-(3-chlorophenyl)-1H-1,2,4-triazole

Base Information

• Chemical Name: 3-(3-chlorophenyl)-1H-1,2,4-triazole
• CAS No.: 52853-74-4
• Molecular Formula: C₈H₆ClN₃
• Molecular Weight: 179.609
• Hs Code.: 2933998090
• Mol file: 52853-74-4.mol

Synonyms:3-(3-chlorophenyl)-1H-1,2,4-triazole

Chemical Property of 3-(3-chlorophenyl)-1H-1,2,4-triazole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-(3-Chlorophenyl)-1,2,4-triazole 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-chlorophenyl)-1H-1,2,4-triazole

There total 14 articles about 3-(3-chlorophenyl)-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-chloro-benzonitrile (766-84-7) → 3-(3-chlorophenyl)-1H-1,2,4-triazole (52853-74-4)

Guidance literature:

With sodium azide; at 120 ℃; for 1.75h;

DOI:10.1007/s11243-016-0115-7

Reference yield: 87.0%

N-(1,2,2,2-tetrachloroethyl)-3-chlorobenzimidoyl chloride → 3-(3-chlorophenyl)-1,2,4-triazole (52853-74-4)

Guidance literature:

With hydrazine hydrate; In chloroform; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2016.10.045

Reference yield: 50.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + 2-chlorobenzamide (609-66-5) → 3-(3-chlorophenyl)-1H-1,2,4-triazole (52853-74-4)

Guidance literature:

N,N-dimethyl-formamide dimethyl acetal; 2-chlorobenzamide; for 1h; Inert atmosphere; Reflux;

With hydrazine hydrate; acetic acid; at 90 ℃;

DOI:10.1021/acs.jmedchem.0c01968

upstream raw materials:

3-diazo-3H-[1,2,4]triazole

chlorobenzene

3-chloro-benzonitrile

C₈H₈ClNS

Downstream raw materials:

(Z)-3-(3-chlorophenyl)-1-(3,3,3-trifluoroprop-1-en-1-yl)-1H-1,2,4-triazol

(Z)-3-[3-(3-chlorophenyl)-[1,2,4]-triazol-1-yl]acrylic acid ethyl ester

(E)-3-[3-(3-chlorophenyl)-[1,2,4]-triazol-1-yl]acrylic acid ethyl ester

C₁₄H₁₄ClN₃O₂

Refernces

• 1、 Azadi, Gouhar,Ghorbani-Choghamarani, Arash,Shiri, Lotfi. "Copper(II) immobilized on Fe3O4@SiO2@l-Histidine: a reusable nanocatalyst and its application in the synthesis of 5-substituted 1H-tetrazoles". . p. 131 - 136. Retrieved 2017/02/23.
• 2、 -. "NUCLEAR TRANSPORT MODULATIORS AND USES THEREOF". . . Retrieved 2011/10/03.