tert-butyl 3-(4-methoxymethoxy-4-phenylpent-2-ynoyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(4-methoxymethoxy-4-phenylpent-2-ynoyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
CAS No.:1379670-76-4
Molecular Formula:C₂₉H₃₀N₄O₅
Molecular Weight:514.581
Hs Code.:

Synonyms:tert-butyl 3-(4-methoxymethoxy-4-phenylpent-2-ynoyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

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Chemical Property of tert-butyl 3-(4-methoxymethoxy-4-phenylpent-2-ynoyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

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Technology Process of tert-butyl 3-(4-methoxymethoxy-4-phenylpent-2-ynoyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

There total 5 articles about tert-butyl 3-(4-methoxymethoxy-4-phenylpent-2-ynoyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093676-94-8
tert-butyl 3-iodo-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

: 15962-97-7
(1-methoxymethoxy-1-methylprop-2-ynyl)benzene

: 13939-06-5,199620-15-0
molybdenum hexacarbonyl

: 1379670-76-4
tert-butyl 3-(4-methoxymethoxy-4-phenylpent-2-ynoyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

Guidance literature:: With copper(l) iodide; tri-tert-butyl phosphine; palladium diacetate; caesium carbonate; In toluene; acetonitrile; at 80 ℃; for 0.0833333h;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1379670-76-4
tert-butyl 3-(4-methoxymethoxy-4-phenylpent-2-ynoyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3.5 h / 10 - 120 °C / Inert atmosphere

2: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1.5 h / 20 °C

3: triethylamine; dmap / dichloromethane / 4 h / 20 °C

4: caesium carbonate; copper(l) iodide; palladium diacetate; tri-tert-butyl phosphine / acetonitrile; toluene / 0.08 h / 80 °C

With dmap; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; iodine; palladium diacetate; sodium carbonate; caesium carbonate; triethylamine; potassium hydroxide; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 918522-51-7
5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-pyridine

: 1379670-76-4
tert-butyl 3-(4-methoxymethoxy-4-phenylpent-2-ynoyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1.5 h / 20 °C

2: triethylamine; dmap / dichloromethane / 4 h / 20 °C

3: caesium carbonate; copper(l) iodide; palladium diacetate; tri-tert-butyl phosphine / acetonitrile; toluene / 0.08 h / 80 °C

With dmap; copper(l) iodide; tri-tert-butyl phosphine; iodine; palladium diacetate; caesium carbonate; triethylamine; potassium hydroxide; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;