[(E)-(S)-6-Iodo-3-(4-methoxy-benzyloxy)-hex-5-enyloxy]-triisopropyl-silane

Base Information

Chemical Name:[(E)-(S)-6-Iodo-3-(4-methoxy-benzyloxy)-hex-5-enyloxy]-triisopropyl-silane
CAS No.:852327-51-6
Molecular Formula:C₂₃H₃₉IO₃Si
Molecular Weight:518.551
Hs Code.:

Synonyms:[(E)-(S)-6-Iodo-3-(4-methoxy-benzyloxy)-hex-5-enyloxy]-triisopropyl-silane

Suppliers and Price of [(E)-(S)-6-Iodo-3-(4-methoxy-benzyloxy)-hex-5-enyloxy]-triisopropyl-silane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(E)-(S)-6-Iodo-3-(4-methoxy-benzyloxy)-hex-5-enyloxy]-triisopropyl-silane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [(E)-(S)-6-Iodo-3-(4-methoxy-benzyloxy)-hex-5-enyloxy]-triisopropyl-silane

There total 9 articles about [(E)-(S)-6-Iodo-3-(4-methoxy-benzyloxy)-hex-5-enyloxy]-triisopropyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 852327-50-5
((S)-3-(4-methoxybenzyloxy)hex-5-ynyloxy)triisopropylsilane

: 852327-51-6
[(E)-(S)-6-Iodo-3-(4-methoxy-benzyloxy)-hex-5-enyloxy]-triisopropyl-silane

Guidance literature:: ((S)-3-(4-methoxybenzyloxy)hex-5-ynyloxy)triisopropylsilane; With Schwartz's reagent; In dichloromethane; at 20 ℃; for 0.75h;

With iodine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.333333h;
DOI:10.1021/jo0477751

Reference yield:

: 852327-34-5
Triisopropyl-((R)-2-oxiranyl-ethoxy)-silane

: 852327-51-6
[(E)-(S)-6-Iodo-3-(4-methoxy-benzyloxy)-hex-5-enyloxy]-triisopropyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 90 percent / BF₃*OEt₂ / tetrahydrofuran; hexane / 1.33 h / -78 - 20 °C

2.1: 2789 mg / camphorsulfonic acid / CH₂Cl₂ / 12 h / 20 °C

3.1: 99 percent / K₂CO₃ / methanol / 1 h / 20 °C

4.1: Cp₂ZrHCl / CH₂Cl₂ / 0.75 h / 20 °C

4.2: 88 percent / I₂ / CH₂Cl₂; tetrahydrofuran / 0.33 h / 20 °C

With Schwartz's reagent; n-butyllithium; camphor-10-sulfonic acid; potassium carbonate; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jo0477751

Reference yield:

: 852327-35-6
(S)-1-Triisopropylsilanyloxy-6-trimethylsilanyl-hex-5-yn-3-ol

: 852327-51-6
[(E)-(S)-6-Iodo-3-(4-methoxy-benzyloxy)-hex-5-enyloxy]-triisopropyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2789 mg / camphorsulfonic acid / CH₂Cl₂ / 12 h / 20 °C

2.1: 99 percent / K₂CO₃ / methanol / 1 h / 20 °C

3.1: Cp₂ZrHCl / CH₂Cl₂ / 0.75 h / 20 °C

3.2: 88 percent / I₂ / CH₂Cl₂; tetrahydrofuran / 0.33 h / 20 °C

With Schwartz's reagent; camphor-10-sulfonic acid; potassium carbonate; In methanol; dichloromethane;
DOI:10.1021/jo0477751