1-Methoxy-4-[(S)-1-(2-triisopropylsilanyloxy-ethyl)-4-trimethylsilanyl-but-3-ynyloxymethyl]-benzene

Base Information

Chemical Name:1-Methoxy-4-[(S)-1-(2-triisopropylsilanyloxy-ethyl)-4-trimethylsilanyl-but-3-ynyloxymethyl]-benzene
CAS No.:852327-36-7
Molecular Formula:C₂₆H₄₆O₃Si₂
Molecular Weight:462.82
Hs Code.:

Synonyms:1-Methoxy-4-[(S)-1-(2-triisopropylsilanyloxy-ethyl)-4-trimethylsilanyl-but-3-ynyloxymethyl]-benzene

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Chemical Property of 1-Methoxy-4-[(S)-1-(2-triisopropylsilanyloxy-ethyl)-4-trimethylsilanyl-but-3-ynyloxymethyl]-benzene

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Technology Process of 1-Methoxy-4-[(S)-1-(2-triisopropylsilanyloxy-ethyl)-4-trimethylsilanyl-but-3-ynyloxymethyl]-benzene

There total 5 articles about 1-Methoxy-4-[(S)-1-(2-triisopropylsilanyloxy-ethyl)-4-trimethylsilanyl-but-3-ynyloxymethyl]-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852327-34-5
Triisopropyl-((R)-2-oxiranyl-ethoxy)-silane

: 852327-36-7
1-Methoxy-4-[(S)-1-(2-triisopropylsilanyloxy-ethyl)-4-trimethylsilanyl-but-3-ynyloxymethyl]-benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 90 percent / BF₃*OEt₂ / tetrahydrofuran; hexane / 1.33 h / -78 - 20 °C

2.1: 2789 mg / camphorsulfonic acid / CH₂Cl₂ / 12 h / 20 °C

With n-butyllithium; camphor-10-sulfonic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo0477751

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 852327-36-7
1-Methoxy-4-[(S)-1-(2-triisopropylsilanyloxy-ethyl)-4-trimethylsilanyl-but-3-ynyloxymethyl]-benzene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / imidazole / tetrahydrofuran / 5.5 h / 20 °C

2.1: 83 percent / m-CPBA / CH₂Cl₂ / 12 h / 20 °C

3.1: 46 percent / H₂O; acetic acid; (R,R)-salen-Co-Cl / tetrahydrofuran / 12 h / 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: 90 percent / BF₃*OEt₂ / tetrahydrofuran; hexane / 1.33 h / -78 - 20 °C

5.1: 2789 mg / camphorsulfonic acid / CH₂Cl₂ / 12 h / 20 °C

With 1H-imidazole; n-butyllithium; (R,R)-salen-Co-Cl; camphor-10-sulfonic acid; water; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo0477751

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 852327-36-7
1-Methoxy-4-[(S)-1-(2-triisopropylsilanyloxy-ethyl)-4-trimethylsilanyl-but-3-ynyloxymethyl]-benzene

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran; various solvent(s) / 2 h / 20 °C

2: 2789 mg / camphorsulfonic acid / CH₂Cl₂ / 12 h / 20 °C

With camphor-10-sulfonic acid; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0477751