(E)-3-[(2S)-N-benzyloxycarbonyl-2-piperidinyl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

Base Information

Chemical Name:(E)-3-[(2S)-N-benzyloxycarbonyl-2-piperidinyl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene
CAS No.:341544-02-3
Molecular Formula:C₃₀H₄₅NO₄
Molecular Weight:483.692
Hs Code.:

Synonyms:(E)-3-[(2S)-N-benzyloxycarbonyl-2-piperidinyl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

Suppliers and Price of (E)-3-[(2S)-N-benzyloxycarbonyl-2-piperidinyl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-3-[(2S)-N-benzyloxycarbonyl-2-piperidinyl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-3-[(2S)-N-benzyloxycarbonyl-2-piperidinyl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

There total 1 articles about (E)-3-[(2S)-N-benzyloxycarbonyl-2-piperidinyl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 505-18-0
2,3,4,5-tetrahydropyridine

: 501-53-1,94274-21-2
benzyl chloroformate

: 257861-22-6
acrolein (R,R)-1,2-dicyclohexylethylene acetal

: 341544-02-3
(E)-3-[(2S)-N-benzyloxycarbonyl-2-piperidinyl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

: (E)-3-[(2R)-N-benzyloxycarbonyl-2-piperidinyl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

Guidance literature:: acrolein (R,R)-1,2-dicyclohexylethylene acetal; With titanium(IV) isopropylate; isopropylmagnesium chloride; In diethyl ether; at -50 - -40 ℃; for 1.5h;

2,3,4,5-tetrahydropyridine; In diethyl ether; at -40 - 20 ℃; for 4h;

benzyl chloroformate; Further stages. Title compound not separated from byproducts.;
DOI:10.1021/ja004140k

Reference yield:

: 108-24-7
acetic anhydride

: 341544-02-3
(E)-3-[(2S)-N-benzyloxycarbonyl-2-piperidinyl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

: (S)-2-[(E)-3-((1R,2R)-2-Acetoxy-1,2-dicyclohexyl-ethoxy)-allyl]-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1021/ja004140k

Reference yield:

: 341544-02-3
(E)-3-[(2S)-N-benzyloxycarbonyl-2-piperidinyl]-1-[(1R,2R)-2-hydroxy-1,2-dicyclohexylethyl]oxy-1-propene

: (S)-2-(3,3-dimethoxypropyl)piperidine benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 20 °C

2: p-TsOH

With pyridine; toluene-4-sulfonic acid;
DOI:10.1021/ja004140k