2-Pyridineglycolonitrile,alpha-methyl-(6CI)

Base Information

• Chemical Name: 2-Pyridineglycolonitrile,alpha-methyl-(6CI)
• CAS No.: 99584-78-8
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.164
• Mol file: 99584-78-8.mol

Synonyms:2-Pyridineglycolonitrile,a-methyl- (6CI);2-Hydroxy-2-(pyridin-2-yl)propanenitrile

Chemical Property of 2-Pyridineglycolonitrile,alpha-methyl-(6CI)

Chemical Property:

• PSA: 56.91000
• LogP: 0.81268

Purity/Quality:

a-hydroxy-a-methyl-2-Pyridineacetonitrile 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pyridineglycolonitrile,alpha-methyl-(6CI)

There total 3 articles about 2-Pyridineglycolonitrile,alpha-methyl-(6CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetylpyridine (1122-62-9) + trimethylsilyl cyanide (7677-24-9) → (RS)-2-acetylpyridine cyanohydrin (99584-78-8)

Guidance literature:

2-acetylpyridine; trimethylsilyl cyanide; zinc(II) iodide; In tetrahydrofuran; at 70 ℃; for 2.5h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 2h;

Reference yield:

2-acetylpyridine (1122-62-9) + potassium cyanide (151-50-8) → (RS)-2-acetylpyridine cyanohydrin (99584-78-8)

Guidance literature:

With hydrogenchloride; at -4 ℃;

DOI:10.1002/ardp.19592920108

Reference yield:

2-acetylpyridine (1122-62-9) + potassium cyanide → (RS)-2-acetylpyridine cyanohydrin (99584-78-8)

Guidance literature:

With sodium disulfite;

DOI:10.1021/jo100445d

upstream raw materials:

2-acetylpyridine

potassium cyanide

trimethylsilyl cyanide

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