1-[(4-fluorophenyl)methyl] -4-hydroxy-2-oxo-1,2-dihydroquinoline- 3-carbonitrile

Base Information

Chemical Name:1-[(4-fluorophenyl)methyl] -4-hydroxy-2-oxo-1,2-dihydroquinoline- 3-carbonitrile
CAS No.:1356152-70-9
Molecular Formula:C₁₇H₁₁FN₂O₂
Molecular Weight:294.285
Hs Code.:

Synonyms:1-[(4-fluorophenyl)methyl] -4-hydroxy-2-oxo-1,2-dihydroquinoline- 3-carbonitrile

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Chemical Property of 1-[(4-fluorophenyl)methyl] -4-hydroxy-2-oxo-1,2-dihydroquinoline- 3-carbonitrile

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Technology Process of 1-[(4-fluorophenyl)methyl] -4-hydroxy-2-oxo-1,2-dihydroquinoline- 3-carbonitrile

There total 7 articles about 1-[(4-fluorophenyl)methyl] -4-hydroxy-2-oxo-1,2-dihydroquinoline- 3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 40534-52-9
N-(4-fluorobenzyl)isatoic anhydride

: 105-56-6
ethyl 2-cyanoacetate

: 1356152-70-9
1-[(4-fluorophenyl)methyl] -4-hydroxy-2-oxo-1,2-dihydroquinoline- 3-carbonitrile

Guidance literature:: N-(4-fluorobenzyl)isatoic anhydride; ethyl 2-cyanoacetate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1.5h;

With hydrogenchloride; In water; N,N-dimethyl-formamide; mineral oil; for 0.5h;

Reference yield: 95.0%

: 2-[(2-cyanoacetyl)-(4-fluorobenzyl)amino]benzoic acid ethyl ester

: 1356152-70-9
1-[(4-fluorophenyl)methyl] -4-hydroxy-2-oxo-1,2-dihydroquinoline- 3-carbonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 1356152-70-9
1-[(4-fluorophenyl)methyl] -4-hydroxy-2-oxo-1,2-dihydroquinoline- 3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

1.2: 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 20 °C

2.2: 0.5 h

With sodium hydride; In N,N-dimethyl-formamide; mineral oil;