40534-52-9

Upstream product

• 118-48-9 isatoic anhydride 
• 7440-44-0 pyrographite 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 459-46-1 4-Fluorobenzyl bromide 
• 124-38-9 carbon dioxide 
• 201230-82-2 carbon monoxide 
• 1040308-57-3 N-(4-fluorobenzyl)-2-iodoaniline 

Downstream Products

• 40534-73-4 2-(4-fluorobenzylamino)benzoic acid 
• 77336-53-9 10-(4-Fluoro-benzyl)-4b-methylsulfanyl-4b,10-dihydro-10,11-diaza-benzo[b]fluoren-5-one 
• 89545-05-1 [1-(4-Fluoro-benzyl)-4-oxo-1,4-dihydro-quinolin-2-yl]-acetic acid ethyl ester 
• 59134-54-2 2-allylamino-1-(4-fluoro-benzyl)-1H-quinazolin-4-one 
• 57513-50-5 1-(4-fluoro-benzyl)-2-methylamino-1H-quinazolin-4-one 
• 55536-40-8 2-amino-1-(4-fluorobenzyl)quinazolin-4(1H)-one 
• 64675-78-1 ethyl 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate 
• 1174735-50-2 C₂₅H₂₀FN₃O₆S₂ 
• 1356152-69-6 1-(4-fluorobenzyl)-2-oxo-4-[4-(thiophen-2ylcarbonyl)piperidin-1-yl]-1,2-dihydroquinoline-3-carbonitrile 
• 749865-60-9 4-chloro-1-(4-fluorobenzyl)-2-oxo-1,2-dihydroquinoline-3-carbonitrile 
• 1356152-70-9 1-[(4-fluorophenyl)methyl] -4-hydroxy-2-oxo-1,2-dihydroquinoline- 3-carbonitrile 
• 1259320-80-3 2-(4-fluorobenzylamino)benzamide 
• 1259320-90-5 11a-chloro-10-(4-fluorobenzyl)benzo[e]oxazolo[3,2-a]-[1,4]diazepine-2,3,5,11(10H,11aH)-tetraone 
• 1259320-83-6 1-(4-fluorobenzyl)-1H-benzo[e][1,4]diazepine-2,3,5(4H)-trione 

Relevant academic research and scientific papers

One-Pot Total Synthesis of Evodiamine and Its Analogues through a Continuous Biscyclization Reaction

The one-pot total synthesis of evodiamine and its analogues is achieved using a three-component reaction. Through continuous biscyclization, various readily available substrates with good functional group tolerance were easily incorporated into biologically active quinazolinocarboline backbones. The use of triethoxymethane as a cosolvent was crucial for this quick and straightforward transformation.

IMPROVED SOLUBILITY FOR TARGET COMPOUNDS

The present disclosure relates to compounds having an improved solubility thereby increasing their bioavailability, lower dosages, etc. The target compounds, may include but are not limited to, macrophage migration inhibitory factor (MIF) inhibitors, epid

Palladium-Catalyzed Cyclization Reaction of o-Iodoanilines, CO2, and CO: Access to Isatoic Anhydrides

Isatoic anhydrides, a class of valuable synthetic intermediates and RNA structure probing reagents, are usually prepared with highly toxic phosgene or stoichiometric oxidants. Herein we report a highly selective palladium-catalyzed cyclization reaction for the efficient synthesis of isatoic anhydrides from readily available o-iodoanilines, CO2, and CO. The reaction proceeds under mild conditions and is redox-neutral. Both CO2 and CO are indispensable C1 building blocks for this catalytic reaction.

MIF INHIBITORS AND THEIR USES

The invention relates to MIF inhibitors; compositions comprising an effective amount of a MIF inhibitor; and methods for treating or preventing diseases associated with MIF.

INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME

Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures (Ia), (Ib) including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

Pharmacologically active tricyclic quinazolinones

The compounds are biologically active tricyclic quinazolinones of the class of imidazo[2,1-b]quinazolin-5-ones, pyrimido[2,1-b]quinazolin-6-ones and diazepino[2,1-b]quinazolin-7-ones, useful, for example, as bronchodilator agents. Processes for preparatio