(S)-methyl 3-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl) ethyl)-5-phenylthiazole-4-carboxamido)benzoate

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Chemical Name:(S)-methyl 3-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl) ethyl)-5-phenylthiazole-4-carboxamido)benzoate
CAS No.:1489277-85-1
Molecular Formula:C₄₄H₃₈N₄O₅S
Molecular Weight:734.876
Hs Code.:

Synonyms:(S)-methyl 3-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl) ethyl)-5-phenylthiazole-4-carboxamido)benzoate

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Chemical Property of (S)-methyl 3-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl) ethyl)-5-phenylthiazole-4-carboxamido)benzoate

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Technology Process of (S)-methyl 3-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl) ethyl)-5-phenylthiazole-4-carboxamido)benzoate

There total 7 articles about (S)-methyl 3-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl) ethyl)-5-phenylthiazole-4-carboxamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 830-96-6
Indole-3-propionic acid

: C₃₃H₂₉N₃O₄S

: 1489277-85-1
(S)-methyl 3-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl) ethyl)-5-phenylthiazole-4-carboxamido)benzoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 1489279-14-2
(S)-methyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxamido)benzoate

: 1489277-85-1
(S)-methyl 3-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl) ethyl)-5-phenylthiazole-4-carboxamido)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; ethyl acetate;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 1489279-11-9
(S)-2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxylic acid

: 1489277-85-1
(S)-methyl 3-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl) ethyl)-5-phenylthiazole-4-carboxamido)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: HATU; 4-methyl-morpholine / dichloromethane / 20 °C

2: hydrogenchloride / ethyl acetate / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; In dichloromethane; ethyl acetate;
DOI:10.1016/j.ejmech.2013.09.017