2-(5,5-Diphenyl-pent-4-enyl)-malonic acid monoethyl ester

Base Information

• Chemical Name: 2-(5,5-Diphenyl-pent-4-enyl)-malonic acid monoethyl ester
• CAS No.: 167562-50-7
• Molecular Formula: C₂₂H₂₄O₄
• Molecular Weight: 352.43
• Mol file: 167562-50-7.mol

Synonyms:2-(5,5-Diphenyl-pent-4-enyl)-malonic acid monoethyl ester

Chemical Property of 2-(5,5-Diphenyl-pent-4-enyl)-malonic acid monoethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(5,5-Diphenyl-pent-4-enyl)-malonic acid monoethyl ester

There total 1 articles about 2-(5,5-Diphenyl-pent-4-enyl)-malonic acid monoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(5,5-Diphenyl-pent-4-enyl)-malonic acid diethyl ester (167562-46-1) → 2-(5,5-Diphenyl-pent-4-enyl)-malonic acid monoethyl ester (167562-50-7)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Heating;

Reference yield:

2-(5,5-Diphenyl-pent-4-enyl)-malonic acid monoethyl ester (167562-50-7) → 2-Chlorocarbonyl-7,7-diphenyl-hept-6-enoic acid ethyl ester

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In benzene; for 3h;

Reference yield:

2-(5,5-Diphenyl-pent-4-enyl)-malonic acid monoethyl ester (167562-50-7) → 7,7-Diphenyl-hept-6-enoic acid diethylamide (202336-97-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) oxalyl chloride, 2.) Et₃N / 1.) benzene, 5 deg C, 2.) Et₂O, 12 h

2: 93 percent / LiOH / aq. ethanol / 5 h / Heating

3: 77 percent / 0.5 h / 170 - 175 °C

With lithium hydroxide; oxalyl dichloride; triethylamine; In ethanol;

DOI:10.1021/jo9717907

upstream raw materials:

2-(5,5-Diphenyl-pent-4-enyl)-malonic acid diethyl ester

Downstream raw materials:

2-Diethylcarbamoyl-7,7-diphenyl-hept-6-enoic acid ethyl ester

7,7-Diphenyl-hept-6-enoic acid diethylamide

2-Diethylcarbamoyl-7,7-diphenyl-hept-6-enoic acid