t-butyl 3-bromo-4-[[[N-(2-phenylethyl)-N-t-butoxycarbonyl]amino]methyl]benzoate

Base Information

• Chemical Name: t-butyl 3-bromo-4-[[[N-(2-phenylethyl)-N-t-butoxycarbonyl]amino]methyl]benzoate
• CAS No.: 160952-48-7
• Molecular Formula: C₂₅H₃₂BrNO₄
• Molecular Weight: 490.437
• Mol file: 160952-48-7.mol

Synonyms:t-butyl 3-bromo-4-[[[N-(2-phenylethyl)-N-t-butoxycarbonyl]amino]methyl]benzoate

Chemical Property of t-butyl 3-bromo-4-[[[N-(2-phenylethyl)-N-t-butoxycarbonyl]amino]methyl]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of t-butyl 3-bromo-4-[[[N-(2-phenylethyl)-N-t-butoxycarbonyl]amino]methyl]benzoate

There total 7 articles about t-butyl 3-bromo-4-[[[N-(2-phenylethyl)-N-t-butoxycarbonyl]amino]methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + t-butyl 3-bromo-4-[[(2-phenylethyl)amino]methyl]-benzoate (160952-47-6) → t-butyl 3-bromo-4-[[[N-(2-phenylethyl)-N-t-butoxycarbonyl]amino]methyl]benzoate (160952-48-7)

Guidance literature:

In chloroform;

Reference yield: 99.0%

→ t-butyl 3-bromo-4-[[(2-phenylethyl)amino]methyl]-benzoate (160952-47-6) + t-butyl 3-bromo-4-[[[N-(2-phenylethyl)-N-t-butoxycarbonyl]amino]methyl]benzoate (160952-48-7)

Guidance literature:

Reference yield:

3-bromo-4-methylbenzoic acid (7697-26-9) → t-butyl 3-bromo-4-[[[N-(2-phenylethyl)-N-t-butoxycarbonyl]amino]methyl]benzoate (160952-48-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 91 percent / 5 mole percent TfOH / diethyl ether / -78 - 20 °C

2: NBS, (PhCO₂)2O / CCl₄ / Heating

3: 49 percent / tetrahydrofuran / Ambient temperature

4: CHCl₃ / Ambient temperature

With N-Bromosuccinimide; trifluorormethanesulfonic acid; (PhCO₂)2O; In tetrahydrofuran; tetrachloromethane; diethyl ether; chloroform;

DOI:10.1016/0040-4039(94)02273-E

upstream raw materials:

di-tert-butyl dicarbonate

t-butyl 3-bromo-4-[[(2-phenylethyl)amino]methyl]-benzoate

3-bromo-4-methylbenzoic acid

phenethylamine

Downstream raw materials:

2-[1-{5-tert-Butoxycarbonyl-2-[(tert-butoxycarbonyl-phenethyl-amino)-methyl]-phenyl}-meth-(Z)-ylidene]-succinic acid dimethyl ester

{7-[(4-{Amino-[(E)-benzyloxycarbonylimino]-methyl}-phenyl)-methyl-carbamoyl]-3-oxo-2-phenethyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl}-acetic acid methyl ester

methyl (R,S)-7-[[[4-(aminoiminomethyl)phenyl]methylamino]-carbonyl]-2,3,4,5-tetrahydro-3-oxo-2-(2-phenylethyl)-1H-2-benzazepine-4-acetate

methyl 3-methoxycarbonyl-4-[5-(t-butoxycarbonyl)-2-[[[N-(2-phenylethyl)-N-t-butoxycarbonyl]amino]methyl]-phenyl]butanoate